Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients

被引：70
作者：
Gieffers, J
Reusche, E
Solbach, W
Maass, M
机构：
[1] Univ Lubeck, Inst Med Microbiol & Hyg, D-23538 Lubeck, Germany
[2] Univ Lubeck, Inst Pathol, D-23538 Lubeck, Germany
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2000年 / 38卷 / 02期
关键词：
D O I：
10.1128/JCM.38.2.881-882.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A recent North American study detected Chlamydia pneumoniae in 17 of 19 brains of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraffin-embedded tissue samples of 20 AD patients by nested PCR and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae-specific DNA nor chlamydial antigens; From our data, the presence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable.
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页码：881 / 882
页数：2
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