Structure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides: Antioxidant, Antiprotozoal, and Antipropulsive Activities

被引：33

作者：

Bustos-Brito, Celia ^{[1
]}

Joseph-Nathan, Pedro ^{[2
]}

Burgueno-Tapia, Eleuterio ^{[3
]}

Martinez-Otero, Diego ^{[4
]}

Nieto-Camacho, Antonio ^{[1
]}

Calzada, Fernando ^{[5
]}

Yepez-Mulia, Lilian ^{[6
]}

Esquivel, Baldomero ^{[1
]}

Quijano, Leovigildo ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico

[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Quim, Apartado 14-740, Mexico City 07000, DF, Mexico

[3] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Quim Orgn, Mexico City 11340, DF, Mexico

[4] UNAM, UAEM, Ctr Conjunto Invest Quim Sustentable, Carretera Toluca Atlacomulco,Km 14-5, Toluca 50200, Mexico

[5] Ctr Med Nacl Siglo XXI, UMAE, IMSS, Unidad Invest Med Farmacol,Hosp Especialidades, Ave Cuauhtemoc 330, Mexico City 06725, DF, Mexico

[6] Ctr Med Nacl Siglo XXI, UMAE, Unidad Invest Med Enfermedades Infecciosas & Para, IMSS,Hosp Especialidades, Ave Cuauhtemoc 330, Mexico City 06725, DF, Mexico

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 05期

关键词：

LIPID-PEROXIDATION; LAMIACEAE; PRODUCTS; MEXICO;

D O I：

10.1021/acs.jnatprod.8b00952

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The aerial parts of Salvia clinopodioides afforded abietanes 1a, 2a, and 3 (clinopodiolides A-C), two of which possess an unusual lactol moiety at C-19-C-20, together with an icetexane named clinopodiolide D (4a). Their structures were established by spectroscopic means, mainly H-1 and C-13 NMR, including 1D and 2D homo- and heteronuclear experiments. The antioxidant, antiprotozoal, and antidiarrheal effects of the isolates were evaluated. Compounds 2a and 3 showed better effects than a-tocopherol in the inhibition of lipid peroxidation with IC50 (mu M) = 5.9 +/- 0.1 and 2.7 +/- 0.2, respectively, and moderate activity in the DPPH assay. All tested compounds showed moderate antiamoebic and antigiardial activity, as well as a good antipropulsive effect.

引用

页码：1207 / 1216

页数：10

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