Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling

被引：80

作者：

Beckers, Johannes ^{[1
,2
]}

Wurst, Wolfgang ^{[2
,3
]}

de Angelis, Martin Hrabe ^{[1
,2
]}

机构：

[1] Helmholtz Zentrum Munchen GmbH, Inst Expt Genet, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Ctr Life & Food Sci, D-85354 Freising Weihenstephan, Germany

[3] Helmholtz Zentrum Munchen GmbH, Inst Dev Genet, D-85764 Neuherberg, Germany

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 06期

关键词：

MICE LACKING VIMENTIN; COLLABORATIVE CROSS; MUTAGENESIS SCREEN; RNA INTERFERENCE; GENE-FUNCTION; GENOME-WIDE; FUNCTIONAL ANNOTATION; MOTOR COORDINATION; ENU MUTAGENESIS; COMPLEX TRAITS;

D O I：

10.1038/nrg2578

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions-the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.

引用

页码：371 / 380

页数：10

共 112 条

[1] Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import [J].

Ahting, Uwe ;

Floss, Thomas ;

Uez, Nikolas ;

Schneider-Lohmar, Ilka ;

Becker, Lore ;

Kling, Eva ;

Iuso, Arcangela ;

Bender, Andreas ;

de Angelis, Martin Hrabe ;

Gailus-Durner, Valerie ;

Fuchs, Helmut ;

Meitinger, Thomas ;

Wurst, Wolfgang ;

Prokisch, Holger ;

Klopstock, Thomas .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2009, 1787 (05) :371-376

[2]

[Anonymous], 1998, Ecotargets, Goal Functions and Orientors Eds

[3] Efficient and fast targeted production of murine models based on ENU mutagenesis [J].

Augustin, M ;

Sedlmeier, R ;

Peters, T ;

Huffstadt, U ;

Kochmann, E ;

Simon, D ;

Schöniger, M ;

Garke-Mayerthaler, S ;

Laufs, J ;

Mayhaus, M ;

Franke, S ;

Klose, M ;

Graupner, A ;

Kurzmann, M ;

Zinser, C ;

Wolf, A ;

Voelkel, M ;

Kellner, M ;

Kilian, M ;

Seelig, S ;

Koppius, A ;

Teubner, A ;

Korthaus, D ;

Nehls, M ;

Wattler, S .

MAMMALIAN GENOME, 2005, 16 (06) :405-413

[4] The knockout mouse project [J].

Austin, CP ;

Battey, JF ;

Bradley, A ;

Bucan, M ;

Capecchi, M ;

Collins, FS ;

Dove, WF ;

Duyk, G ;

Dymecki, S ;

Eppig, JT ;

Grieder, FB ;

Heintz, N ;

Hicks, G ;

Insel, TR ;

Joyner, A ;

Koller, BH ;

Lloyd, KCK ;

Magnuson, T ;

Moore, MW ;

Nagy, A ;

Pollock, JD ;

Roses, AD ;

Sands, AT ;

Seed, B ;

Skarnes, WC ;

Snoddy, J ;

Soriano, P ;

Stewart, DJ ;

Stewart, F ;

Stillman, B ;

Varmus, H ;

Varticovski, L ;

Verma, IM ;

Vogt, TF ;

von Melchner, H ;

Witkowski, J ;

Woychik, RP ;

Wurst, W ;

Yancopoulos, GD ;

Young, SG ;

Zambrowicz, B .

NATURE GENETICS, 2004, 36 (09) :921-924

[5] The European dimension for the mouse genome mutagenesis program [J].

Auwerx, J ;

Avner, P ;

Baldock, R ;

Ballabio, A ;

Balling, R ;

Barbacid, M ;

Berns, A ;

Bradley, A ;

Brown, S ;

Carmeliet, P ;

Chambon, P ;

Cox, R ;

Davidson, D ;

Davies, K ;

Duboule, D ;

Forejt, J ;

Granucci, F ;

Hastie, N ;

de Angelis, MH ;

Jackson, I ;

Kioussis, D ;

Kollias, G ;

Lathrop, M ;

Lendahl, U ;

Malumbres, M ;

von Melchner, H ;

Müller, W ;

Partanen, J ;

Ricciardi-Castagnoli, P ;

Rigby, P ;

Rosen, B ;

Rosenthal, N ;

Skarnes, B ;

Stewart, AF ;

Thornton, J ;

Tocchini-Valentini, G ;

Wagner, E ;

Wahli, W ;

Wurst, W .

NATURE GENETICS, 2004, 36 (09) :925-927

[6] ENU mutagenesis: Analyzing gene function in mice [J].

Balling, R .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2001, 2 :463-492

[7] Generation and characterization of dickkopf3 mutant mice [J].

Barrantes, ID ;

Montero-Pedrazuela, A ;

Guadaño-Ferraz, A ;

Obregon, MJ ;

de Mena, RM ;

Gailus-Durner, V ;

Fuchs, H ;

Franz, TJ ;

Kalaydjiev, S ;

Klempt, M ;

Hölter, S ;

Rathkolb, B ;

Reinhard, C ;

de Escobar, GM ;

Bernal, J ;

Busch, DH ;

Wurst, W ;

Wolf, E ;

Schulz, H ;

Shtrom, S ;

Greiner, E ;

de Angelis, MH ;

Westphal, H ;

Niehrs, C .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (06) :2317-2326

[8] Creatine improves health and survival of mice [J].

Bender, A. ;

Beckers, J. ;

Schneider, I. ;

Hoelter, S. M. ;

Haack, T. ;

Ruthsatz, T. ;

Vogt-Weisenhorn, D. M. ;

Becker, L. ;

Genius, J. ;

Rujescu, D. ;

Irmler, M. ;

Mijalski, T. ;

Mader, M. ;

Quintanilla-Martinez, L. ;

Fuchs, H. ;

Gailus-Durner, V. ;

de Angelis, M. Hrabe ;

Wurst, W. ;

Schmid, J. ;

Klopstock, T. .

NEUROBIOLOGY OF AGING, 2008, 29 (09) :1404-1411

[9]

Bibikova M, 2002, GENETICS, V161, P1169

[10] Mouse Phenome Project: understanding human biology through mouse genetics and genomics [J].

Bogue, M .

JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (04) :1335-1337

← 1 2 3 4 5 6 7 8 9 10 →