Rational Design of Magnetic Nanorattles as Contrast Agents for Ultrasound/Magnetic Resonance Dual-Modality Imaging

被引:32
作者
Yang, Peng [1 ,2 ]
Wang, Fang [1 ,2 ]
Luo, Xianfu [3 ]
Zhang, Yuting [1 ,2 ]
Guo, Jia [1 ,2 ]
Sho, Weibin [4 ]
Wang, Changchun [1 ,2 ]
机构
[1] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
[2] Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China
[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Radiol, Shanghai 200025, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai 200092, Peoples R China
基金
美国国家科学基金会;
关键词
nanorattle; iron oxide; contrast agent; ultrasound imaging; MRI; IRON-OXIDE NANOPARTICLES; FUTURE-DIRECTIONS; MRI; THERAPY; NANOCAPSULES; ENHANCEMENT; FABRICATION; TOMOGRAPHY; ABLATION; HIFU;
D O I
10.1021/am502550b
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Nanorattles, as promising functional hollow nanomaterials, show considerable advantages in a variety of applications for drug delivery, biosensors, and biomedical imaging because of their tailored ability in both the movable core and shell. In this study, we formulate a facile controllable route to synthesize a monodisperse magnetic nanorattle with an Fe3O4 superparticle as the core and poly(vinylsilane) (PVS) as the outer shell (Fe3O4@air@PVS) using the polymer-backbone-transition strategy. In the process of synthesis, besides acting as the precursor for the PVS shells of nanorattles, organosilica (o-SiO2) plays the role of template for the middle cavities. The structures of nanorattles can be easily formed via etching treatment of NaOH solution. Through encapsulating sensitive perfluorohexane (PFH) in the cavities of Fe3O4@air@PVS, the biocompatible magnetic nanosystem shows a relatively stable ultrasound signal intensity and a high r(2) value of 62.19 mM(-1) s(-1) for magnetic resonance imaging (MRI). After intravenous administration of nanorattles to a healthy rat, dramatically positively enhanced ultrasound imaging and negatively enhanced T-2-weighted MRI are detected in the liver. Furthermore, when the Fe3O4@PFH@PVS nanorattles are administered to tumor-bearing mice, a significant passive accumulation in the tumor via an electron paramagnetic resonance effect is detected by both ultrasound imaging and MRI. In vivo experiments indicate that the obtained Fe3O4@PFH@PVS nanorattles can be used as dual-modality contrast agents for simultaneous ultrasound and MRI detection.
引用
收藏
页码:12581 / 12587
页数:7
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共 41 条
  • [11] Single photon-emission computed tomography
    Holly, Thomas A.
    Abbott, Brian G.
    Al-Mallah, Mouaz
    Calnon, Dennis A.
    Cohen, Mylan C.
    DiFilippo, Frank P.
    Ficaro, Edward P.
    Freeman, Michael R.
    Hendel, Robert C.
    Jain, Diwakar
    Leonard, Scott M.
    Nichols, Kenneth J.
    Polk, Donna M.
    Soman, Prem
    [J]. JOURNAL OF NUCLEAR CARDIOLOGY, 2010, 17 (05) : 941 - 973
  • [12] SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy
    Huang, Hsin-Yang
    Hu, Shang-Hsiu
    Hung, Shih-Ya
    Chiang, Chih-Sheng
    Liu, Hao-Li
    Chiu, Tsung-Lang
    Lai, Hsin-Yi
    Chen, You-Yin
    Chen, San-Yuan
    [J]. JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) : 118 - 127
  • [13] Multifunctional nanoparticles for multimodal imaging and theragnosis
    Lee, Dong-Eun
    Koo, Heebeom
    Sun, In-Cheol
    Ryu, Ju Hee
    Kim, Kwangmeyung
    Kwon, Ick Chan
    [J]. CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) : 2656 - 2672
  • [14] Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents
    Lee, Nohyun
    Hyeon, Taeghwan
    [J]. CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) : 2575 - 2589
  • [15] Doxorubicin-Conjugated Mesoporous Magnetic Colloidal Nanocrystal Clusters Stabilized by Polysaccharide as a Smart Anticancer Drug Vehicle
    Li, Dian
    Tang, Jing
    Wei, Chuan
    Guo, Jia
    Wang, Shilong
    Chaudhary, Deeptangshu
    Wang, Changchun
    [J]. SMALL, 2012, 8 (17) : 2690 - 2697
  • [16] Ultrabubble: A Laminated Ultrasound Contrast Agent with Narrow Size Range
    Lin, Pei-Lun
    Eckersley, Robert J.
    Hall, Elizabeth A. H.
    [J]. ADVANCED MATERIALS, 2009, 21 (38-39) : 3949 - +
  • [17] Microbubbles in medical imaging: current applications and future directions
    Lindner, JR
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (06) : 527 - 532
  • [18] Synthesis of Magnetic Rattle-Type Nanostructures for Use in Water Treatment
    Linley, Stuart
    Leshuk, Timothy
    Gu, Frank X.
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (07) : 2540 - 2548
  • [19] Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging
    Liu, Zhe
    Lammers, Twan
    Ehling, Josef
    Fokong, Stanley
    Bornemann, Joerg
    Kiessling, Fabian
    Gaetjens, Jessica
    [J]. BIOMATERIALS, 2011, 32 (26) : 6155 - 6163
  • [20] Hollow Micro-/Nanostructures: Synthesis and Applications
    Lou, Xiong Wen
    Archer, Lynden A.
    Yang, Zichao
    [J]. ADVANCED MATERIALS, 2008, 20 (21) : 3987 - 4019