Immunology - Sugar determines antibody activity

被引：64

作者：

Burton, Dennis R.

Dwek, Raymond A.

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Univ Oxford, Dept Biochem, Glycobiol Inst, Oxford OX1 3QU, England

来源：

SCIENCE | 2006年 / 313卷 / 5787期

关键词：

D O I：

10.1126/science.1131712

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding the functional consequences of the identity and sequence of the sugars attached to antibodies may be useful in designing therapies for a range of disorders.

引用

页码：627 / 628

页数：2

共 12 条

[1] Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease [J].

Bruhns, P ;

Samuelsson, A ;

Pollard, JW ;

Ravetch, JV .

IMMUNITY, 2003, 18 (04) :573-581

[2] The carbohydrate at FcγRIIIa Asn-162 -: an element required for high affinity binding to non-fucosylated IgG glycoforms [J].

Ferrara, C ;

Stuart, F ;

Sondermann, P ;

Brükner, P ;

Umaña, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (08) :5032-5036

[3] Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation [J].

Kaneko, Yoshikatsu ;

Nimmerjahn, Falk ;

Ravetch, Jeffrey V. .

SCIENCE, 2006, 313 (5787) :670-673

[4] Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity [J].

Krapp, S ;

Mimura, Y ;

Jefferis, R ;

Huber, R ;

Sondermann, P .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (05) :979-989

[5] GLYCOSYLATION CHANGES OF IGG ASSOCIATED WITH RHEUMATOID-ARTHRITIS CAN ACTIVATE COMPLEMENT VIA THE MANNOSE-BINDING PROTEIN [J].

MALHOTRA, R ;

WORMALD, MR ;

RUDD, PM ;

FISCHER, PB ;

DWEK, RA ;

SIM, RB .

NATURE MEDICINE, 1995, 1 (03) :237-243

[6] Role of oligosaccharide residues of IgG1-Fc in FcγRIIb binding [J].

Mimura, Y ;

Sondermann, P ;

Ghirlando, R ;

Lund, J ;

Young, SP ;

Goodall, M ;

Jefferis, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (49) :45539-45547

[7] Divergent immunoglobulin G subclass activity through selective Fc receptor binding [J].

Nimmerjahn, F ;

Ravetch, JV .

SCIENCE, 2005, 310 (5753) :1510-1512

[8] IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides [J].

Niwa, R ;

Natsume, A ;

Uehara, A ;

Wakitani, M ;

Iida, S ;

Uchida, K ;

Satoh, M ;

Shitara, K .

JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 306 (1-2) :151-160

[9] ASSOCIATION OF RHEUMATOID-ARTHRITIS AND PRIMARY OSTEO-ARTHRITIS WITH CHANGES IN THE GLYCOSYLATION PATTERN OF TOTAL SERUM IGG [J].

PAREKH, RB ;

DWEK, RA ;

SUTTON, BJ ;

FERNANDES, DL ;

LEUNG, A ;

STANWORTH, D ;

RADEMACHER, TW ;

MIZUOCHI, T ;

TANIGUCHI, T ;

MATSUTA, K ;

TAKEUCHI, F ;

NAGANO, Y ;

MIYAMOTO, T ;

KOBATA, A .

NATURE, 1985, 316 (6027) :452-457

[10] Selection, design, and engineering of therapeutic antibodies [J].

Presta, LG .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (04) :731-736

← 1 2 →