Deep-Sea-Derived Butyrolactone I Suppresses Ovalbumin-Induced Anaphylaxis by Regulating Mast Cell Function in a Murine Model

被引：35

作者：

Liu, Qing-Mei ^{[1
]}

Xie, Chun-Lan ^{[2
]}

Gao, Yuan-Yuan ^{[1
]}

Liu, Bo ^{[1
]}

Lin, Wei-Xiang ^{[2
]}

Liu, Hong ^{[1
]}

Cao, Min-Jie ^{[1
]}

Su, Wen-Jin ^{[1
]}

Yang, Xian-Wen ^{[2
]}

Liu, Guang-Ming ^{[1
]}

机构：

[1] Jimei Univ, Fujian Collaborat Innovat Ctr Exploitat & Utiliza, Fujian Prov Engn Technol Res Ctr Marine Funct Foo, Xiamen Key Lab Marine Funct Food,Coll Food Biol E, 43 Yindou Rd, Xiamen 361021, Fujian, Peoples R China

[2] State Ocean Adm, Inst Oceanog 3, South China Sea Bioresource Exploitat & Utilizat, Key Lab Marine Biogenet Resources, 184 Daxue Rd, Xiamen 361005, Fujian, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 22期

关键词：

OVA anaphylaxis; deep-sea fungus; butyrolactone I; antifood allergy; mast cell; Fc gamma RIIB; ALLERGIC RESPONSES; BASOPHIL; MOUSE; IGE; DEGRANULATION; OLIGOSACCHARIDES; PREVALENCE; ACTIVATION; INHIBITION; RECEPTORS;

D O I：

10.1021/acs.jafc.8b01674

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Deep-sea-derived butyrolactone I (BTL-I), which was identified as a type of butanolide, was isolated from Aspergillus sp. Ovalbumin (OVA)-induced BALB/c anaphylaxis was established to explore the antifood allergic activity of BTL-I. As a result, BTL-I was able to alleviate OVA-induced allergy symptoms, reduce the levels of histamine and mouse mast cell proteinases, inhibit OVA-specific IgE, and decrease the population of mast cells in the spleen and mesenteric lymph nodes. BTL-I also significantly suppressed mast-dependent passive cutaneous anaphylaxis. Additionally, the maturation of bone marrow-derived mast cells (BMMCs) declined as BTL-I caused down-regulation of c-KIT receptors. Furthermore, molecular docking analyses revealed that BTL-I interacted with the inhibitory receptor, Fc gamma RIIB. In conclusion, the reduction of mast cell function by deep-sea-derived BTL-I as well as its interactions with the inhibitory receptor, Fc gamma RIIB, may contribute to BTL-I-related protection against food anaphylaxis.

引用

页码：5581 / 5592

页数：12

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