Anticoagulation therapy in microsurgery: A review

被引：91

作者：

Askari, Morad

Fisher, Christine

Weniger, Frederick G.

Bidic, Sean

Lee, W. P. Andrew

机构：

[1] Univ Pittsburgh, Sch Med, Div Plast Surg, Pittsburgh, PA 15261 USA

[2] Univ So Calif, Div Plast & Reconstruct Surg, Los Angeles, CA USA

[3] Univ Pittsburgh, Med Ctr, Dept Plast & Reconstruct Surg, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 2006年 / 31A卷 / 05期

关键词：

microsurgery; anticoagulation; thrombosis; flap; heparin;

D O I：

10.1016/j.jhsa.2006.02.023

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The advent of microsurgical tissue transfer including replantation greatly has expanded the scope of reconstructive surgery. There are few recent innovations in anticoagulation therapies for microsurgery, however, an anastomatic thrombosis remains an occasional cause of surgical failure. No concensus exists on the ideal anticoagulation protocol for microsurgey. This article reviews major pharmacologic modalities of anticoagulation, delineates the mechanism of action and study of efficacy of each agent, and compares the risk and benefits of popular anticoagulation therapies. Finally, it examines available human outcomes-based data and attempts to provide a glimpse of the future direction of microsurgical anticoagulation research.

引用

页码：836 / 846

页数：11

共 98 条

[1] Patency of different arterial and venous end-to-side microanastomosis techniques in a rat model [J].