Copper deficiency myelopathy (human swayback)

被引:209
作者
Kumar, Neeraj [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Coll Med, Dept Neurol, Rochester, MN 55905 USA
关键词
D O I
10.4065/81.10.1371
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The hematologic manifestations of copper deficiency are well known and include anemia and neutropenia. In the past few years, the neurological manifestations of acquired copper deficiency in humans has been recognized, the most common being a myelopathy presenting with a spastic gait and prominent sensory ataxia. The known causes of acquired copper deficiency include prior gastric surgery, excessive zinc ingestion, and malabsorption; however, often the cause is unclear. Hyperzincemia may be present even in the absence of exogenous zinc ingestion. The clinical features and neuroimaging findings are similar to the subacute combined degeneration seen in patients with vitamin B-12 deficiency. Copper and vitamin B-12 deficiency may coexist. The neurological syndrome may be present without the hematologic manifestations. Copper supplementation resolves the anemia and neutropenia promptly and completely and may prevent the neurological deterioration. Improvement, when it occurs, is often subjective and preferentially involves sensory symptoms. This article describes patients with copper deficiency myelopathy seen at the Mayo Clinic in Rochester, Minn, and reviews the literature on neurological manifestations of acquired copper deficiency in humans.
引用
收藏
页码:1371 / 1384
页数:14
相关论文
共 115 条
[21]   COPPER DEFICIENCY AND CENTRAL NERVOUS-SYSTEM - MYELINATION IN RAT - MORPHOLOGICAL AND BIOCHEMICAL STUDIES [J].
DIPAOLO, RV ;
KANFER, JN ;
NEWBERNE, PM .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1974, 33 (02) :226-236
[22]   ANEMIA AND NEUTROPENIA CAUSED BY COPPER DEFICIENCY [J].
DUNLAP, WM ;
JAMES, GW ;
HUME, DM .
ANNALS OF INTERNAL MEDICINE, 1974, 80 (04) :470-476
[23]  
EVERSON GLADYS J., 1967, J NUTR, V93, P533
[24]   PERIPHERAL NEUROPATHY AND STARVATION AFTER GASTRIC PARTITIONING FOR MORBID-OBESITY [J].
FEIT, H ;
GLASBERG, M ;
IRETON, C ;
ROSENBERG, RN ;
THAL, E .
ANNALS OF INTERNAL MEDICINE, 1982, 96 (04) :453-455
[25]   ZINC-INDUCED SIDEROBLASTIC ANEMIA - REPORT OF A CASE, REVIEW OF THE LITERATURE, AND DESCRIPTION OF THE HEMATOLOGIC SYNDROME [J].
FISKE, DN ;
MCCOY, HE ;
KITCHENS, CS .
AMERICAN JOURNAL OF HEMATOLOGY, 1994, 46 (02) :147-150
[26]   Pancytopenia after removal of copper from total parenteral nutrition [J].
Fuhrman, MP ;
Herrmann, V ;
Masidonski, P ;
Eby, C .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2000, 24 (06) :361-366
[27]   UNUSUAL NEUROLOGICAL DISORDER OF COPPER-METABOLISM CLINICALLY RESEMBLING WILSONS DISEASE BUT BIOCHEMICALLY A DISTINCT ENTITY [J].
GODWINAUSTEN, RB ;
ROBINSON, A ;
EVANS, K ;
LASCELLES, PT .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1978, 39 (01) :85-98
[28]  
GORDON RS, 1959, LANCET, V1, P325
[29]  
GRAHAM GG, 1969, JOHNS HOPKINS MED J, V124, P139
[30]  
Green P, 2004, AM BOOK REV, V25, P1