ESHRE Task Force on Ethics and Law22: Preimplantation Genetic Diagnosis

被引:37
作者
De Wert, G. [1 ,2 ]
Dondorp, W. [1 ,2 ]
Shenfield, F. [3 ]
Devroey, P. [4 ]
Tarlatzis, B. [5 ]
Barri, P. [6 ]
Diedrich, K. [7 ]
Provoost, V. [8 ]
Pennings, G. [8 ]
机构
[1] Maastricht Univ, Dept Hlth Eth & Soc, Res Inst CAPHRI, NL-6200 MD Maastricht, Netherlands
[2] Maastricht Univ, Dept Hlth Eth & Soc, Res Inst GROW, NL-6200 MD Maastricht, Netherlands
[3] Univ Coll London Hosp, Obstetr Hosp, Reprod Med Unit, London WC1 6AU, England
[4] UZ Brussel, Ctr Reprod Med, Brussels, Belgium
[5] Aristotle Univ Thessaloniki, Infertil & IVF Ctr, Dept OB GYN, Sch Med, Thessaloniki, Greece
[6] Univ Dexeus, Dept Obstet, Serv Med Reprod, Barcelona, Spain
[7] Med Univ Lubeck, Dept Obstet & Gynaecol, D-23538 Lubeck, Germany
[8] Univ Ghent, Dept Philosophy, B-9000 Ghent, Belgium
关键词
ethics; PGD; indications; transfer decisions; MITOCHONDRIAL-DNA DISORDERS; HUNTINGTONS-DISEASE;
D O I
10.1093/humrep/deu132
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
This Task Force document discusses some relatively unexplored ethical issues involved in preimplantation genetic diagnosis (PGD). The document starts from the wide consensus that PGD is ethically acceptable if aimed at helping at-risk couples to avoid having a child with a serious disorder. However, if understood as a limit to acceptable indications for PGD, this 'medical model' may turn out too restrictive. The document discusses a range of possible requests for PGD that for different reasons fall outwith the accepted model and argues that instead of rejecting those requests out of hand, they need to be independently assessed in the light of ethical criteria. Whereas, for instance, there is no good reason for rejecting PGD in order to avoid health problems in a third generation (where the second generation would be healthy but faced with burdensome reproductive choices if wanting to have children), using PGD to make sure that one's child will have the same disorder or handicap as its parents, is ethically unacceptable.
引用
收藏
页码:1610 / 1617
页数:8
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