BrettPhos Ligand Supported Palladium-Catalyzed C-O Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides

被引：60

作者：

Rangarajan, T. M. ^{[1
,3
]}

Singh, Rajendra ^{[2
]}

Brahma, Raju ^{[2
]}

Devi, Kavita ^{[2
]}

Singh, Rishi Pal ^{[1
]}

Singh, R. P. ^{[2
]}

Prasad, Ashok K. ^{[3
]}

机构：

[1] Univ Delhi, Sri Venkateswara Coll, Dept Chem, New Delhi, India

[2] DRDO, Fluoroorgan Lab, Ctr Fire Explos & Environm Safety, Delhi, India

[3] Univ Delhi, Dept Chem, Delhi 110007, India

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 44期

关键词：

alcohols; BrettPhos; CO coupling; ethers; reductive elimination; CROSS-COUPLING REACTIONS; ALPHA-FLUORINATED ETHERS; BETA-AMYLOID PLAQUES; DIARYL ETHERS; 2,2,2-TRIFLUOROETHYL ETHERS; AROMATIC FLUOROALKOXYLATION; AMINATION REACTIONS; EFFICIENT CATALYST; PHOSPHINE-LIGANDS; PRIMARY ALCOHOLS;

D O I：

10.1002/chem.201404121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report an unprecedented BrettPhos ligand supported Pd-catalyzed CO bond-forming reaction of activated aryl halides with primary fluoroalkyl alcohols. We demonstrate that the Phosphine ligand (BrettPhos) possesses the property of altering the mechanistic pathway of reductive elimination from nucleophile to nucleophile. The Pd/BrettPhos catalyst system facilitates the reductive elimination of the oxygen nucleophile through an electronic pathway.

引用

页码：14218 / 14225

页数：8