In vitro aceclofenac release from IPN matrix tablets composed of chitosan-tamarind seed polysaccharide

被引：13

作者：

Jana, Sougata ^{[1
]}

Sen, Kalyan Kumar ^{[1
]}

Basu, Sanat Kumar ^{[2
]}

机构：

[1] Gupta Coll Technol Sci, Dept Pharmaceut, Asansol 713301, WB, India

[2] Jadavpur Univ, Dept Pharmaceut Technol, Div Pharmaceut, Kolkata 700032, WB, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 65卷

关键词：

Chitosan; Tamarind seed polysaccharide; Matrix tablet; RESPONSE-SURFACE METHODOLOGY; CONTROLLED DRUG-DELIVERY; METFORMIN HCL; MUCOADHESIVE BEADS; VIVO EVALUATION; NATURAL GUMS; XANTHAN GUM; POLYMER; FORMULATION; MICROSPHERES;

D O I：

10.1016/j.ijbiomac.2014.01.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This communication describes the formulation and in vitro evaluation of IPN matrix tablets of aceclofenac. IPN microparticles using chitosan and tamarind seed polysaccharide blend was prepared using glutaraldehyde as cross-linker. The drug entrapment efficiency and average particle size of these microparticles was found to be 91.97 +/- 130% and 498.12 +/- 38.67 mu m, respectively. These IPN microparticles were characterized by scanning electron microscopy (SEM) and powder X-ray diffraction (P-XRD) study. These microparticles were compressed with tablet excipients through direct compression technique. These matrix tablets showed sustained aceclofenac release over 8 h. These matrix tablets might be helpful to minimize dosing frequency and reduction of various side effects during prolong period of treatment. (c) 2014 Published by Elsevier B.V.

引用

页码：241 / 245

页数：5

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