Fabrication and testing of porous Ti microneedles for drug delivery

被引：22

作者：

Yan, Xiao-Xiao ^{[1
]}

Liu, Jing-Quan ^{[1
]}

Jiang, Shui-Dong ^{[1
]}

Yang, Bin ^{[1
]}

Yang, Chun-Sheng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Inst Micro & Nano Sci & Technol, Natl Key Lab Sci & Technol Nano Micro Fabricat, Shanghai 200240, Peoples R China

来源：

MICRO & NANO LETTERS | 2013年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

biomedical materials; diseases; drug delivery systems; drugs; etching; microorganisms; needles; porous materials; skin; titanium; microfabrication; Ti; size; 20; mum; distance; 800; disease treatment; rats; insulin injection; skins; piercing; shear forces; microholes; organisms; wet etching; cutting; porous metal microneedles; drug delivery; porous titanium microneedle testing; porous titanium microneedle fabrication; SKIN; PERMEATION; EXPOSURE;

D O I：

10.1049/mnl.2013.0630

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Porous metal microneedles were fabricated by an incorporated process of cutting and wet etching. Each microneedle is comprised of many connecting microholes that can deliver drugs into organisms conveniently and efficiently. The microneedle height is larger than 400 m, the pitch distance is about 800 m and the microholes in each microneedle are about 20 m in diameter. In force testing, the microneedles could resist large shear forces and pierce into skins easily; in the in vivo experiment, the insulin was efficiently injected into rats by a patch of the microneedles. The testing and the experiment demonstrated that the microneedles could deliver drugs into organisms to treat diseases without fracture.

引用

页码：906 / 908

页数：3

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