Aziridine alkaloids as potential therapeutic agents

被引：208

作者：

Ismail, Fyaz M. D. ^{[3
]}

Levitsky, Dmitri O. ^{[2
]}

Dembitsky, Valery M. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Univ Nantes, Fac Sci & Technol, CNRS, UMR 6204, F-44037 Nantes 03, France

[3] Liverpool John Moores Univ, Dept Pharm & Chem, Med Chem Res Grp, Liverpool L3 3AF, Merseyside, England

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 09期

关键词：

Alkaloids; Aziridine; Synthesis; Anticancer; Antibacterial; Pharmacological activity; Micro-organisms; Plants; Invertebrates; MITOMYCIN BIOSYNTHETIC-PATHWAY; SPONGE DYSIDEA-FRAGILIS; FATTY-ACID DERIVATIVES; ANTITUMOR ANTIBIOTICS; ACTINOMADURA-MADURAE; N-METHYLTRANSFERASE; CYSTEINE PROTEASES; ALKYLATING-AGENTS; CROSS-LINKING; AZINOMYCIN-B;

D O I：

10.1016/j.ejmech.2009.05.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present review describes research on natural aziridine alkaloids isolated from both terrestrial and marine species, as well as their lipophilic semi-synthetic, and/or synthetic analogs. Over 130 biologically active aziridine-containing compounds demonstrate confirmed pharmacological activity including antitumor, antimicrobial, antibacterial effects. The structures, origin, and biological activities of aziridine alkaloids are reviewed. Consequently this review emphasizes the role of aziridine alkaloids as an important source of drug prototypes and leads for drug discovery. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3373 / 3387

页数：15

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