Aziridine alkaloids as potential therapeutic agents

被引：208

作者：

Ismail, Fyaz M. D. ^{[3
]}

Levitsky, Dmitri O. ^{[2
]}

Dembitsky, Valery M. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Univ Nantes, Fac Sci & Technol, CNRS, UMR 6204, F-44037 Nantes 03, France

[3] Liverpool John Moores Univ, Dept Pharm & Chem, Med Chem Res Grp, Liverpool L3 3AF, Merseyside, England

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 09期

关键词：

Alkaloids; Aziridine; Synthesis; Anticancer; Antibacterial; Pharmacological activity; Micro-organisms; Plants; Invertebrates; MITOMYCIN BIOSYNTHETIC-PATHWAY; SPONGE DYSIDEA-FRAGILIS; FATTY-ACID DERIVATIVES; ANTITUMOR ANTIBIOTICS; ACTINOMADURA-MADURAE; N-METHYLTRANSFERASE; CYSTEINE PROTEASES; ALKYLATING-AGENTS; CROSS-LINKING; AZINOMYCIN-B;

D O I：

10.1016/j.ejmech.2009.05.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present review describes research on natural aziridine alkaloids isolated from both terrestrial and marine species, as well as their lipophilic semi-synthetic, and/or synthetic analogs. Over 130 biologically active aziridine-containing compounds demonstrate confirmed pharmacological activity including antitumor, antimicrobial, antibacterial effects. The structures, origin, and biological activities of aziridine alkaloids are reviewed. Consequently this review emphasizes the role of aziridine alkaloids as an important source of drug prototypes and leads for drug discovery. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3373 / 3387

页数：15

共 156 条

[1] Aminocyclopentitols from N-alkylpyridinium salts:: A photochemical approach [J].

Acar, EA ;

Glarner, F ;

Burger, U .

HELVETICA CHIMICA ACTA, 1998, 81 (06) :1095-1104

[2]

Argoudelis A.D., 1976, US Patent, Patent No. [542226 19760224, 542226]

[3] ANTIBIOTICS PRODUCED BY STREPTOMYCES-FICELLUS .1. FICELLOMYCIN [J].

ARGOUDELIS, AD ;

REUSSER, F ;

WHALEY, HA ;

BACZYNSKYJ, L ;

MIZSAK, SA ;

WNUK, RJ .

JOURNAL OF ANTIBIOTICS, 1976, 29 (10) :1001-1006

[4] Characteristics of the antitumor activity of M-16 and M-18, major metabolites of a new mitomycin C derivative KW-2149, in mice [J].

Ashizawa, T ;

Okamoto, A ;

Okabe, M ;

Kobayashi, S ;

Arai, H ;

Saito, H ;

Kasai, M ;

Gomi, K .

ANTI-CANCER DRUGS, 1995, 6 (06) :763-770

[5] PROTON AFFINITIES, IONIZATION-POTENTIALS, AND HYDROGEN AFFINITIES OF NITROGEN AND OXYGEN BASES - HYBRIDIZATION EFFECTS [J].

AUE, DH ;

WEBB, HM ;

BOWERS, MT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (14) :4137-4139

[6]

BATRAKOV SG, 1967, ZH OBSHCH KHIM, V37, P426

[7] FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo [J].

Beckerbauer, L ;

Tepe, JJ ;

Cullison, J ;

Reeves, R ;

Williams, RM .

CHEMISTRY & BIOLOGY, 2000, 7 (10) :805-812

[8] The formation and stabillity of spiro-compounds. Part I. Spiro-compounds from cyclo-hexane. [J].

Beesley, RM ;

Ingold, CK ;

Thorpe, JF .

JOURNAL OF THE CHEMICAL SOCIETY, 1915, 107 :1080-1106

[9] Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase [J].

Belcourt, MF ;

Hodnick, WF ;

Rockwell, S ;

Sartorelli, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :456-460

[10]

BICKER U, 1978, FORTSCHR MED, V96, P661

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