DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus

被引：35

作者：

Zhou, Zheng ^{[1
]}

Sun, Bao ^{[2
,3
]}

Li, Xiaoping ^{[1
]}

Zhu, Chunsheng ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chinese Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410000, Hunan, Peoples R China

[3] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410000, Hunan, Peoples R China

来源：

NUTRITION & METABOLISM | 2018年 / 15卷

关键词：

T2DM; DNA methylation; Insulin secretion; Insulin resistance; Insulin-sensitive organs; EPIGENOME-WIDE ASSOCIATION; INSULIN-RESISTANCE; PANCREATIC-ISLETS; ADIPOSE-TISSUE; EPIGENETIC DYSREGULATION; GENETIC ARCHITECTURE; PERIPHERAL-BLOOD; SKELETAL-MUSCLE; EXPRESSION; PROMOTER;

D O I：

10.1186/s12986-018-0283-x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of pancreatic beta cells and the body's resistance to insulin. Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. This review summarized the role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells, comparing the tissue similarity and specificity of methylated genes, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease.

引用

页数：8

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