Lipid rafts and assembly of enveloped viruses

被引:78
作者
Suomalainen, M [1 ]
机构
[1] Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden
关键词
assembly; budding; Ebola; HIV-1; influenza; lipid rafts;
D O I
10.1034/j.1600-0854.2002.31002.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The plasma membrane, late secretory pathway and endosomal compartments contain detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol. Rafts are currently an intensively studied topic of cell biology, and raft involvement has been implicated in numerous cellular processes. A number of recent reports have localized structural proteins of several enveloped viruses to rafts, thus raising the possibility that rafts also play a role in the assembly and budding of viruses, but what exactly that role might be is still unknown.
引用
收藏
页码:705 / 709
页数:5
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