Valuing live births from assisted reproduction: A health economics viewpoint

Infertility is a medical condition that can be overcome, thanks to advances in medically assisted reproductive (MAR) therapies. Despite the ultimate measure of MAR efficacy being the birth of a new human being, there are ethical and methodological questions as to which outcome best translates the value of MAR in cost-effectiveness analyses. Many authors favour cost per life birth outcomes instead of more traditional cost per quality-adjusted life years (QALYs), which raises generalizability issues for decision-makers. Nonetheless, infertility and infertility treatments sub-stantially differ from other health conditions and health treat-ments, particularly in the way they affect the quality of life of the infertile couple. Collecting quality of life measures in infertility and pregnancy is also surrounded by challenges not easily overcome. We reflect on cost-effectiveness methods applied to MAR tech-nologies, on ethical considerations for valuing a MAR-generated life, and on its broader societal value for consideration by deci-sion-makers.(c) 2022 Published by Elsevier Ltd.