Direct metal-free O-arylation of Biginelli 4-aryl-6-methyl-pyrimidine-2(1H)-one derivatives using diaryliodonium salts

被引：16

作者：

Thorat, Prerana B. ^{[1
]}

Waghmode, Nitin A. ^{[1
]}

Karade, Nandkishor N. ^{[1
]}

机构：

[1] Rashtrasant Tukadoji Maharaj Nagpur Univ, Dept Chem, Nagpur 440033, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 42期

关键词：

Biginelli reaction; 4-Aryl-6-methyl-pyrimidine-2(1H)-one; Heteroaryl ether; C-O cross-coupling; Diaryliodonium salts; ONE-POT SYNTHESIS; EFFICIENT; PYRIMIDINES; INHIBITORS; IODINE; OPTIMIZATION; CHEMISTRY;

D O I：

10.1016/j.tetlet.2014.08.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Aryl-6-methyl-pyrimidine-2(1H)-one scaffolds of Biginelli type were subjected to C-O cross-coupling reactions using symmetrical diaryliodonium salts under transition metal-free conditions to afford 2-aryl-oxy pyrimidine derivatives in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5718 / 5721

页数：4

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