Targeting the PD-1/PD-L1 Axis in Human Vitiligo

被引：19

作者：

Willemsen, Marcella ^{[1
,2
]}

Melief, Cornelis J. M. ^{[3
]}

Bekkenk, Marcel W. ^{[1
,2
]}

Luiten, Rosalie M. ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Amsterdam Univ Med Ctr, Canc Ctr Amsterdam,Dept Dermatol, Amsterdam Infect & Immun Inst,Locat AMC, Amsterdam, Netherlands

[2] Univ Amsterdam, Amsterdam Univ Med Ctr, Canc Ctr Amsterdam,Netherlands Inst Pigment Disor, Amsterdam Infect & Immun Inst,Locat AMC, Amsterdam, Netherlands

[3] ISA Pharmaceut, Leiden, Netherlands

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

vitiligo; programmed cell death 1 receptor; B7-H1; antigen; immune tolerance; autoimmunity; NONMELANOMA SKIN-CANCER; REGULATORY T-CELLS; STAGE-III; MELANOMA; AUTOIMMUNITY; PD-L1; EXPRESSION; NIVOLUMAB; RESPONSES; BLOCKADE;

D O I：

10.3389/fimmu.2020.579022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoreactive CD8(+) T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can break peripheral tolerance against self-antigens in the skin. Therapeutically enhancing immune checkpoint signaling by immune cells or skin cells, making self-reactive T cells anergic, seems a promising therapeutic option for vitiligo. Here, we review the current knowledge on the PD-1/PD-L1 pathway in vitiligo as new therapeutic target for vitiligo therapy.

引用

页数：7

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