IL-17 Promotes Murine Lupus

被引：113

作者：

Amarilyo, Gil ^{[1
]}

Lourenco, Elaine V. ^{[1
]}

Shi, Fu-Dong ^{[2
]}

La Cava, Antonio ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA

[2] St Josephs Hosp, Barrow Neurol Inst, Div Neurol, Phoenix, AZ 85013 USA

来源：

JOURNAL OF IMMUNOLOGY | 2014年 / 193卷 / 02期

关键词：

T-CELLS; TH17; CELLS; INTERLEUKIN-17; ASSOCIATION; NEPHRITIS; INTERPLAY; PRISTANE; DISEASE; MICE;

D O I：

10.4049/jimmunol.1400931

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17-deficient mice was associated with a reduced frequency of CD3(+)CD4(-)CD8(-) double-negative T cells and an expansion of CD4(+) regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE.

引用

页码：540 / 543

页数：4

共 24 条

[1] Interplay Between Effector Th17 and Regulatory T Cells [J].

Awasthi, Amit ;

Murugaiyan, Gopal ;

Kuchroo, Vijay K. .

JOURNAL OF CLINICAL IMMUNOLOGY, 2008, 28 (06) :660-670

[2] Plasma IL-17A Is Increased in New-Onset SLE Patients and Associated with Disease Activity [J].

Chen, Xiao Qi ;

Yu, Yan Cheng ;

Deng, Hao Hua ;

Sun, Jia Zhong ;

Dai, Zhe ;

Wu, Yu Wen ;

Yang, Miao .

JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (02) :221-225

[3] Interleukin-17-producing T cells in lupus [J].

Crispin, Jose C. ;

Tsokos, George C. .

CURRENT OPINION IN RHEUMATOLOGY, 2010, 22 (05) :499-503

[4] Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys [J].

Crispin, Jose C. ;

Oukka, Mohamed ;

Bayliss, George ;

Cohen, Robert A. ;

Van Beek, Christine A. ;

Stillman, Isaac E. ;

Kyttaris, Vasileios C. ;

Juang, Yuang-Taung ;

Tsokos, George C. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (12) :8761-8766

[5] Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice [J].

Dong, J. ;

Wang, Q-X ;

Zhou, C-Y ;

Ma, X-F ;

Zhang, Y-C .

LUPUS, 2007, 16 (02) :101-109

[6] Protection against renal disease in (NZB x NZW)F1 lupus-prone mice after somatic B cell gene vaccination with anti-DNA immunoglobulin consensus peptide [J].

Ferrera, Francesca ;

Hahn, Bevra H. ;

Rizzi, Marta ;

Anderson, Marissa ;

FitzGerald, John ;

Millo, Enrico ;

Indiveri, Francesco ;

Shi, Fu-Dong ;

Filaci, Gilberto ;

La Cava, Antonio .

ARTHRITIS AND RHEUMATISM, 2007, 56 (06) :1945-1953

[7] Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice [J].

Hsu, Hui-Chen ;

Yang, PingAr ;

Wang, John ;

Wu, Qi ;

Myers, Riley ;

Chen, Jian ;

Yi, John ;

Guentert, Tanja ;

Tousson, Albert ;

Stanus, Andrea L. ;

Le, Thuc-vy L. ;

Lorenz, Robin G. ;

Xu, Hui ;

Kolls, Jay K. ;

Carter, Robert H. ;

Chaplin, David D. ;

Williams, Robert W. ;

Mountz, John D. .

NATURE IMMUNOLOGY, 2008, 9 (02) :166-175

[8] Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice [J].

Kyttaris, Vasileios C. ;

Kampagianni, Ourania ;

Tsokos, George C. .

BIOMED RESEARCH INTERNATIONAL, 2013, 2013

[9] Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6-lpr/lpr Mice [J].

Kyttaris, Vasileios C. ;

Zhang, Zheng ;

Kuchroo, Vijay K. ;

Oukka, Mohamed ;

Tsokos, George C. .

JOURNAL OF IMMUNOLOGY, 2010, 184 (09) :4605-4609

[10] T-regulatory cells in systemic lupus erythematosus [J].

La Cava, A. .

LUPUS, 2008, 17 (05) :421-425

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