Decreased Ventilatory Response to Hypercapnia in Dementia with Lewy Bodies

被引：26

作者：

Mizukami, Katsuyoshi ^{[1
]}

Homma, Toshiaki ^{[2
]}

Aonuma, Kazutaka ^{[3
]}

Kinoshita, Toru ^{[4
]}

Kosaka, Kenji ^{[5
]}

Asada, Takashi

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan

[2] Teikyo Univ, Chiba Med Ctr, Div Resp Dis, Ichihara, Chiba, Japan

[3] Univ Tsukuba, Dept Cardiol, Tsukuba, Ibaraki 3058575, Japan

[4] Kodama Clin, Tokyo, Japan

[5] Yokohama Hoyu Hosp, Yokohama, Kanagawa, Japan

来源：

ANNALS OF NEUROLOGY | 2009年 / 65卷 / 05期

关键词：

IMPAIRED CHEMOSENSITIVITY; AUTONOMIC DYSFUNCTION; DIAGNOSIS; DLB; MARKER;

D O I：

10.1002/ana.21613

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A systematic autonomic dysfunction observed among patients with dementia with Lewy bodies (DLB) has recently attracted close attention. Here, we compare cardiovascular and pulmonary autonomic functions among patients with DLB, patients with Alzheimer's disease, and healthy control subjects. All 15 DLB patients demonstrated severely low ventilatory response to hypercapnia, whereas none of the other subjects demonstrated abnormal results. The majority of the DLB patients showed impaired heart rate variability, low up-take on I-123-metaiodobenzylguanidine myocardial scintigraphy, and orthostatic hypotension. Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB.

引用

页码：614 / 617

页数：4

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