The structural basis of TGF-β, bone morphogenetic protein, and activin ligand binding

被引：108
作者：
Lin, S. Jack
Lerch, Thomas F.
Cook, Robert W.
Jardetzky, Theodore S.
Woodruff, Teresa K.
机构：
[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA
[3] Northwestern Univ, Dept Med, Evanston, IL 60208 USA
来源：
REPRODUCTION | 2006年 / 132卷 / 02期
关键词：
D O I：
10.1530/rep.1.01072
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The transforming growth factor-beta (TGF-beta) superfamily is a large group of structurally related growth factors that play prominent roles in a variety of cellular processes. The importance and prevalence of TGF-beta signaling are also reflected by the complex network of check points that exist along the signaling pathway, including a number of extracellular antagonists and membrane-level signaling modulators. Recently, a number of important TGF-beta crystal structures have emerged and given us an unprecedented clarity on several aspects of the signal transduction process. This review will highlight these latest advances and present our current understanding on the mechanisms of specificity and regulation on TGF-beta signaling outside the cell.
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页码：179 / 190
页数：12
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