Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

被引：11

作者：

Azmi, Fazren ^{[1
,2
]}

Elliott, Alysha G. ^{[3
]}

Khalil, Zeinab G. ^{[3
]}

Hussein, Waleed M. ^{[1
]}

Kavanagh, Angela ^{[3
]}

Huang, Johnny X. ^{[3
]}

Quezada, Michelle ^{[3
]}

Blaskovich, Mark A. T. ^{[3
]}

Capon, Robert J. ^{[3
]}

Cooper, Matthew A.

Skwarczynski, Mariusz ^{[1
]}

Toth, Istvan ^{[1
,3
,4
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

[2] Natl Univ Malaysia, Fac Pharm, Kuala Lumpur, Malaysia

[3] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[4] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia

来源：

NANOMEDICINE | 2015年 / 10卷 / 22期

关键词：

antibacterial activity; Gram-positive bacteria; lipopeptides; multidrug resistant; nanoparticles; self-assembly; CATIONIC ANTIMICROBIAL PEPTIDES; GROUP-A STREPTOCOCCUS; VACCINE CANDIDATE; DRUG-DELIVERY; NANOPARTICLES; AMPHIPHILES; ABSORPTION; MECHANISMS; MEMBRANES; EPITOPE;

D O I：

10.2217/nnm.15.137

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To explore the potential of de novo designed cyclic lipopeptides and its linear counterparts as antibacterial agents. Materials & methods: The lipopeptides were synthesized via solid-phase peptide synthesis and the cyclization was achieved by using succinic acid linker. The antimicrobial activities of the lipopeptides were evaluated in vitro against a variety selection of Gram-negative and Gram-positive bacteria including clinical isolates of multidrug-resistant strains. Results: The synthesized lipopeptides were able to self-assemble into nanoparticles in an aqueous environment, with three exhibiting potent antibacterial activity against Gram-positive bacteria, including clinically relevant multidrug-resistant bacteria. Conclusion: The lead compounds have the potential to be developed as new antibacterials that are effective against Gram-positive bacteria, including multidrug-resistant isolates.

引用

页码：3359 / 3371

页数：13

共 48 条

[1] Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates [J].

Abdel-Aal, Abu-Baker M. ;

Batzloff, Michael R. ;

Fujita, Yoshio ;

Barozzi, Nadia ;

Faria, Andres ;

Simerska, Pavia ;

Moyle, Peter M. ;

Good, Michael F. ;

Toth, Istvan .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (01) :167-172

[2] Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature [J].

Arnison, Paul G. ;

Bibb, Mervyn J. ;

Bierbaum, Gabriele ;

Bowers, Albert A. ;

Bugni, Tim S. ;

Bulaj, Grzegorz ;

Camarero, Julio A. ;

Campopiano, Dominic J. ;

Challis, Gregory L. ;

Clardy, Jon ;

Cotter, Paul D. ;

Craik, David J. ;

Dawson, Michael ;

Dittmann, Elke ;

Donadio, Stefano ;

Dorrestein, Pieter C. ;

Entian, Karl-Dieter ;

Fischbach, Michael A. ;

Garavelli, John S. ;

Goeransson, Ulf ;

Gruber, Christian W. ;

Haft, Daniel H. ;

Hemscheidt, Thomas K. ;

Hertweck, Christian ;

Hill, Colin ;

Horswill, Alexander R. ;

Jaspars, Marcel ;

Kelly, Wendy L. ;

Klinman, Judith P. ;

Kuipers, Oscar P. ;

Link, A. James ;

Liu, Wen ;

Marahiel, Mohamed A. ;

Mitchell, Douglas A. ;

Moll, Gert N. ;

Moore, Bradley S. ;

Mueller, Rolf ;

Nair, Satish K. ;

Nes, Ingolf F. ;

Norris, Gillian E. ;

Olivera, Baldomero M. ;

Onaka, Hiroyasu ;

Patchett, Mark L. ;

Piel, Joern ;

Reaney, Martin J. T. ;

Rebuffat, Sylvie ;

Ross, R. Paul ;

Sahl, Hans-Georg ;

Schmidt, Eric W. ;

Selsted, Michael E. .

NATURAL PRODUCT REPORTS, 2013, 30 (01) :108-160

[3] The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels [J].

Ashrafuzzaman, Md. ;

Andersen, O. S. ;

McElhaney, R. N. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (12) :2814-2822

[4] Self-adjuvanting vaccine against group A streptococcus: Application of fibrillized peptide and immunostimulatory lipid as adjuvant [J].

Azmi, Fazren ;

Fuaad, Abdullah Al Hadi Ahmad ;

Giddam, Ashwini Kumar ;

Batzloff, Michael R. ;

Good, Michael F. ;

Skwarczynski, Mariusz ;

Toth, Istvan .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (22) :6401-6408

[5] Detergent-like actions of linear amphipathic cationic antimicrobial peptides [J].

Bechinger, Burkhard ;

Lohner, Karl .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (09) :1529-1539

[6] Oral absorption and in vivo biodistribution of α-conotoxin MII and a lipidic analogue [J].

Blanchfield, Joanne T. ;

Gallagher, Oliver P. ;

Cros, Cecile ;

Lewis, Richard J. ;

Alewood, Paul F. ;

Toth, Istvan .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (01) :97-102

[7] Vancomycin resistance: occurrence, mechanisms and strategies to combat it [J].

Boneca, IG ;

Chiosis, G .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2003, 7 (03) :311-328

[8] Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? [J].

Brogden, KA .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (03) :238-250

[9] Improved Protease Stability of the Antimicrobial Peptide Pin2 Substituted with D-Amino Acids [J].

Carmona, G. ;

Rodriguez, A. ;

Juarez, D. ;

Corzo, G. ;

Villegas, E. .

PROTEIN JOURNAL, 2013, 32 (06) :456-466

[10] Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action [J].

Chan, David I. ;

Prenner, Elmar J. ;

Vogel, Hans J. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (09) :1184-1202

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