Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines

被引：21

作者：

Sirakanyan, S. N. ^{[1
]}

Ovakimyan, A. A. ^{[1
]}

Noravyan, A. S. ^{[1
]}

Minasyan, N. S. ^{[2
]}

Dzhagatspanyan, I. A. ^{[1
]}

Nazaryan, I. M. ^{[1
]}

Akopyan, A. G. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Mndjoyan Inst Fine Organ Chem, Yerevan 375014, Armenia

[2] Natl Acad Sci Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Mol Struct Res Ctr, Yerevan 375014, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 47卷 / 12期

基金：

美国国家卫生研究院;

关键词：

pyrano[3,4-c]pyridines; thieno[3,2-d]pyrimidines; furo[3,2-d]pyrimidines; cyclization; amino derivatives; neurotropic activity;

D O I：

10.1007/s11094-014-1026-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New derivatives of pyrano[4aEuro(3),3aEuro(3):4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidines based on 3-chloro derivatives of pyrano[3,4-c]pyridines and pyrano[4aEuro(3),3aEuro(3):4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidines based on previously prepared 8-chloro derivatives were synthesized. Studies of the biological activity of the synthesized compounds showed that several of them exhibited neurotropic properties.

引用

页码：655 / 659

页数：5

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