The SWI/SNF complex and cancer

被引：466

作者：

Reisman, D. ^{[1
]}

Glaros, S.

Thompson, E. A. ^{[2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Coll Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

[2] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA

来源：

ONCOGENE | 2009年 / 28卷 / 14期

关键词：

BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling; CHROMATIN-REMODELING COMPLEX; SWI-SNF COMPLEX; TUMOR-SUPPRESSOR GENE; GLUCOCORTICOID-INDUCED APOPTOSIS; CELL-CYCLE ARREST; LUNG-CANCER; ESTROGEN-RECEPTOR; NUCLEAR RECEPTOR; ATPASE SUBUNIT; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.1038/onc.2009.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

引用

页码：1653 / 1668

页数：16

共 216 条

[11]

Biegel Jaclyn A., 2002, Cancer Research, V62, P323

[12] Molecular analysis of pediatric brain tumors [J].

Biegel J.A. ;

Pollack I.F. .

Current Oncology Reports, 2004, 6 (6) :445-452

[13] BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer [J].

Bochar, DA ;

Wang, L ;

Beniya, H ;

Kinev, A ;

Xue, YT ;

Lane, WS ;

Wang, WD ;

Kashanchi, F ;

Shiekhattar, R .

CELL, 2000, 102 (02) :257-265

[14] Evidence that Spt6p controls chromatin structure by a direct interaction with histones [J].

Bortvin, A ;

Winston, F .

SCIENCE, 1996, 272 (5267) :1473-1476

[15]

Bourachot B, 1999, MOL CELL BIOL, V19, P3931

[16] Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation [J].

Bourachot, B ;

Yaniv, M ;

Muchardt, C .

EMBO JOURNAL, 2003, 22 (24) :6505-6515

[17] hSNFS/INII-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities [J].

Bourdeaut, F. ;

Freneaux, P. ;

Thuille, B. ;

Lellouch-Tubiana, A. ;

Nicolas, A. ;

Couturier, J. ;

Pierron, G. ;

Sainte-Rose, C. ;

Bergeron, C. ;

Bouvier, R. ;

Rialland, X. ;

Laurence, V. ;

Michon, J. ;

Sastre-Garau, X. ;

Delattre, O. .

JOURNAL OF PATHOLOGY, 2007, 211 (03) :323-330

[18] The histone acetyltransferase activity of PCAF cooperates with the brahma/SW12-related protein BRG-1 in the activation of the enhancer A of the MHC class I promoter [J].

Brockmann, D ;

Lehmkühler, O ;

Schmücker, U ;

Esche, H .

GENE, 2001, 277 (1-2) :111-120

[19] Drosophila cyclin E interacts with components of the Brahma complex [J].

Brumby, AM ;

Zraly, CB ;

Horsfield, JA ;

Secombe, J ;

Saint, R ;

Dingwall, AK ;

Richardson, H .

EMBO JOURNAL, 2002, 21 (13) :3377-3389

[20] A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes [J].

Bultman, S ;

Gebuhr, T ;

Yee, D ;

La Mantia, C ;

Nicholson, J ;

Gilliam, A ;

Randazzo, F ;

Metzger, D ;

Chambon, P ;

Crabtree, G ;

Magnuson, T .

MOLECULAR CELL, 2000, 6 (06) :1287-1295

← 1 2 3 4 5 6 7 8 9 10 →