The SWI/SNF complex and cancer

被引：467
作者：
Reisman, D. [1 ]
Glaros, S.
Thompson, E. A. [2 ]
机构：
[1] Univ Michigan, Dept Internal Med, Coll Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA
[2] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA
来源：
ONCOGENE | 2009年 / 28卷 / 14期
关键词：
BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling; CHROMATIN-REMODELING COMPLEX; SWI-SNF COMPLEX; TUMOR-SUPPRESSOR GENE; GLUCOCORTICOID-INDUCED APOPTOSIS; CELL-CYCLE ARREST; LUNG-CANCER; ESTROGEN-RECEPTOR; NUCLEAR RECEPTOR; ATPASE SUBUNIT; TRANSCRIPTIONAL ACTIVATION;
D O I：
10.1038/onc.2009.4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
引用
收藏
页码：1653 / 1668
页数：16
相关论文
共 216 条
  • [1] MOLECULAR ANALYSIS OF SNF2 AND SNF5, GENES REQUIRED FOR EXPRESSION OF GLUCOSE-REPRESSIBLE GENES IN SACCHAROMYCES-CEREVISIAE
    ABRAMS, E
    NEIGEBORN, L
    CARLSON, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (11) : 3643 - 3651
  • [2] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter
    Agalioti, T
    Lomvardas, S
    Parekh, B
    Yie, JM
    Maniatis, T
    Thanos, D
    [J]. CELL, 2000, 103 (04) : 667 - 678
  • [3] An HX, 1999, CANCER RES, V59, P3941
  • [4] ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo
    Aoyagi, S
    Trotter, KW
    Archer, TK
    [J]. VITAMINS AND HORMONES, 2005, 70 : 281 - 307
  • [5] The Drosophila BRM complex facilitates global transcription by RNA polymerase II
    Armstrong, JA
    Papoulas, O
    Daubresse, G
    Sperling, AS
    Lis, JT
    Scott, MP
    Tamkun, JW
    [J]. EMBO JOURNAL, 2002, 21 (19) : 5245 - 5254
  • [6] A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro
    Armstrong, JA
    Bieker, JJ
    Emerson, BM
    [J]. CELL, 1998, 95 (01) : 93 - 104
  • [7] SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation
    Banine, F
    Bartlett, C
    Gunawardena, R
    Muchardt, C
    Yaniv, M
    Knudsen, ES
    Weissman, BE
    Sherman, LS
    [J]. CANCER RESEARCH, 2005, 65 (09) : 3542 - 3547
  • [8] The human SWI/SNF subunit Brm is a regulator of alternative splicing
    Batsché, E
    Yaniv, M
    Muchardt, C
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (01) : 22 - 29
  • [9] Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes
    Belandia, B
    Orford, RL
    Hurst, HC
    Parker, MG
    [J]. EMBO JOURNAL, 2002, 21 (15) : 4094 - 4103
  • [10] Biegel JA, 2000, CLIN CANCER RES, V6, P2759
12345678910