Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

被引：236

作者：

Choe, Katherine N. ^{[1
,2
]}

Moldovan, George-Lucian ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA

[2] Harvard Med Sch, Dept Radiat Oncol, Div Genom Stabil & DNA Repair, Dana Farber Canc Inst, Boston, MA 02215 USA

来源：

MOLECULAR CELL | 2017年 / 65卷 / 03期

关键词：

CELL NUCLEAR ANTIGEN; DNA-DAMAGE TOLERANCE; E3 UBIQUITIN LIGASE; OKAZAKI FRAGMENT MATURATION; NUCLEOTIDE EXCISION-REPAIR; S-PHASE; TRANSLESION SYNTHESIS; HOMOLOGOUS RECOMBINATION; POLYMERASE-ETA; MONOUBIQUITINATED PCNA;

D O I：

10.1016/j.molcel.2016.12.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

引用

页码：380 / 392

页数：13

共 158 条

[111] Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin [J].

Plosky, Brian S. ;

Vidal, Antonio E. ;

Fernandez de Henestrosa, Antonio R. ;

McLenigan, Mary P. ;

McDonald, John P. ;

Mead, Samantha ;

Woodgate, Roger .

EMBO JOURNAL, 2006, 25 (12) :2847-2855

[112] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass [J].

Povlsen, Lou K. ;

Beli, Petra ;

Wagner, Sebastian A. ;

Poulsen, Sara L. ;

Sylvestersen, Kathrine B. ;

Poulsen, Jon W. ;

Nielsen, Michael L. ;

Bekker-Jensen, Simon ;

Mailand, Niels ;

Choudhary, Chunaram .

NATURE CELL BIOLOGY, 2012, 14 (10) :1089-+

[113] Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins [J].

Prakash, Rohit ;

Zhang, Yu ;

Feng, Weiran ;

Jasin, Maria .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2015, 7 (04)

[114] Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication [J].

Punchihewa, Chandanamali ;

Inoue, Akira ;

Hishiki, Asami ;

Fujikawa, Yoshihiro ;

Connelly, Michele ;

Evison, Benjamin ;

Shao, Youming ;

Heath, Richard ;

Kuraoka, Isao ;

Rodrigues, Patrick ;

Hashimoto, Hiroshi ;

Kawanishi, Masanobu ;

Sato, Mamoru ;

Yagi, Takashi ;

Fujii, Naoaki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (17) :14289-14300

[115] A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction [J].

Raman, Malavika ;

Havens, Courtney G. ;

Walter, Johannes C. ;

Harper, J. Wade .

MOLECULAR CELL, 2011, 44 (01) :72-84

[116] Defective DNA repair and Neurodegenerative disease [J].

Rass, Ulrich ;

Ahel, Ivan ;

West, Stephen C. .

CELL, 2007, 130 (06) :991-1004

[117] CDK1-dependent Inhibition of the E3 Ubiquitin Ligase CRL4CDT2 Ensures Robust Transition from S Phase to Mitosis [J].

Rizzardi, Lindsay F. ;

Coleman, Kate E. ;

Varma, Dileep ;

Matson, Jacob P. ;

Oh, Seeun ;

Cook, Jeanette Gowen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (01) :556-567

[118] Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression [J].

Roa, Sergio ;

Avdievich, Elena ;

Peled, Jonathan U. ;

MacCarthy, Thomas ;

Werling, Uwe ;

Kuang, Fei Li ;

Kan, Rui ;

Zhao, Chunfang ;

Bergman, Aviv ;

Cohen, Paula E. ;

Edelmann, Winfried ;

Scharff, Matthew D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (42) :16248-16253

[119] The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA [J].

Saugar, Irene ;

Parker, Joanne L. ;

Zhao, Shengkai ;

Ulrich, Helle D. .

NUCLEIC ACIDS RESEARCH, 2012, 40 (01) :245-257

[120] Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans [J].

Sebesta, Marek ;

Burkovics, Peter ;

Juhasz, Szilvia ;

Zhang, Sufang ;

Szabo, Judit E. ;

Lee, Marietta Y. W. T. ;

Haracska, Lajos ;

Krejci, Lumir .

DNA REPAIR, 2013, 12 (09) :691-698

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