Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

被引：244

作者：

Choe, Katherine N. ^{[1
,2
]}

Moldovan, George-Lucian ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA

[2] Harvard Med Sch, Dept Radiat Oncol, Div Genom Stabil & DNA Repair, Dana Farber Canc Inst, Boston, MA 02215 USA

来源：

MOLECULAR CELL | 2017年 / 65卷 / 03期

关键词：

CELL NUCLEAR ANTIGEN; DNA-DAMAGE TOLERANCE; E3 UBIQUITIN LIGASE; OKAZAKI FRAGMENT MATURATION; NUCLEOTIDE EXCISION-REPAIR; S-PHASE; TRANSLESION SYNTHESIS; HOMOLOGOUS RECOMBINATION; POLYMERASE-ETA; MONOUBIQUITINATED PCNA;

D O I：

10.1016/j.molcel.2016.12.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

引用

页码：380 / 392

页数：13

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