One-Pot Selective Homodimerization/Hydrogenation Strategy for Sequential Dicarba Bridge Formation

被引：12

作者：

Burnley, James ^{[1
]}

Jackson, W. Roy ^{[1
]}

Robinson, Andrea J. ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 18期

基金：

澳大利亚研究理事会;

关键词：

ASYMMETRIC-SYNTHESIS; DISULFIDE BRIDGES; METATHESIS; ANALOGS; ACID; RING; HYDROGENATION; PEPTIDES; MIMICS; NISIN;

D O I：

10.1021/acs.joc.5b01312

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The installation of interlocked dicarba bridges into peptide sequences requires the development of a regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt-carbonyl protected alkyne, and an alkene using metathesis and homogeneous hydrogenation catalysis.

引用

收藏

页码：9057 / 9063

页数：7

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