Iodine-catalyzed synthesis of 2-arylpyrazolo[5,1-b]quinazolin-9(3H)-one derivatives in ionic liquids via domino reaction

被引：15

作者：

Zhou, Yu-Jing ^{[1
]}

Zhang, Mei-Mei ^{[1
]}

Li, Yu-Ling ^{[1
]}

Liu, Yun ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Pyrazoloquinazoline; Domino reaction; Iodine; Synthesis; DESULFURIZATION RING CONTRACTION; GROWTH-FACTOR NGF; QUINAZOLINONE DERIVATIVES; AZINES; PYRAZOLOQUINAZOLINONE; PYRAZOLOPYRIMIDINES; 5-AMINOPYRAZOLES; INHIBITORS; ALDEHYDES; RECEPTOR;

D O I：

10.1016/j.tet.2014.03.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The domino reaction of (E)-2-amino-N'-(1-arylethylidene)benzohydrazide and triethyl orthoformate in ionic liquids catalyzed by 10 mol % iodine gave 3a,4-dihydro-2-arylpyrazolo[5,1-b]quinazolin-9(3H)-one derivatives unexpectedly. In the presence of K2S2O8, it could be oxidized to aromatized products in good yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3440 / 3446

页数：7

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