The IL-6 feed-forward loop: A driver of tumorigenesis

被引：87

作者：

Chang, Qing ^{[1
]}

Daly, Laura ^{[1
]}

Bromberg, Jacqueline ^{[1
,2
]}

机构：

[1] MSKCC, Dept Med, New York, NY 10065 USA

[2] WCMC, New York, NY USA

来源：

SEMINARS IN IMMUNOLOGY | 2014年 / 26卷 / 01期

关键词：

Metastasis; Microenvironment; Cancer; MESENCHYMAL STEM-CELLS; NF-KAPPA-B; ANTI-INTERLEUKIN-6; MONOCLONAL-ANTIBODY; DUCTAL BREAST-CARCINOMA; LIGAND-INDUCED ENDOCYTOSIS; SILTUXIMAB CNTO 328; SUPPRESSOR-CELLS; MULTIPLE-MYELOMA; STAT3; ACTIVATION; CANCER-CELLS;

D O I：

10.1016/j.smim.2014.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed. (C) 2014 Published by Elsevier Ltd.

引用

页码：48 / 53

页数：6

共 120 条

[1] Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis [J].