Total synthesis and antihypertensive activity of (±)7,8-dihydroxy-3-methyl-isochromanone-4

被引：28

作者：

Liu, Jie ^{[1
]}

Ren, Hao ^{[1
]}

Xu, Jinyi ^{[1
]}

Bai, Renren ^{[1
]}

Yan, Qi ^{[1
]}

Huang, Wenlong ^{[2
]}

Wu, Xiaoming ^{[2
]}

Fu, Jihua ^{[3
]}

Wang, Qiujuan ^{[3
]}

Wu, Qian ^{[3
]}

Fu, Rong ^{[3
]}

机构：

[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210038, Peoples R China

[3] China Pharmaceut Univ, Dept Physiol, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 06期

关键词：

(+/-)7,8-Dihydroxy-3-methyl-isochromanone-4; Total synthesis; Antihypertensive activity; ACE inhibitors;

D O I：

10.1016/j.bmcl.2008.12.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive activity in renal hypertensive rats and further mechanism studies revealed that it is an ACE inhibitor. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1822 / 1824

页数：3

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