Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes

被引：11

作者：

Kim, Bongju ^{[1
]}

Takeuchi, Ayako ^{[2
]}

Koga, Orie ^{[1
]}

Hikida, Masaki ^{[1
]}

Matsuoka, Satoshi ^{[1
]}

机构：

[1] Kyoto Univ, Ctr Innovat Immunoregulat Technol & Therapeut, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Dept Physiol & Biophys, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan

来源：

SODIUM CALCIUM EXCHANGE: A GROWING SPECTRUM OF PATHOPHYSIOLOGICAL IMPLICATIONS | 2013年 / 961卷

关键词：

Mitochondrial NCX; Calcium; Voltage dependence; Electrogenicity; NCLX; Lymphocytes; Cardiomyocytes; Store-operated Ca2+ entry; PIG VENTRICULAR MYOCYTES; HEART-MITOCHONDRIA; ENDOPLASMIC-RETICULUM; CARDIAC-MUSCLE; OXIDATIVE-PHOSPHORYLATION; ESSENTIAL COMPONENT; NA+/CA2+ EXCHANGER; CALCIUM UNIPORTER; SODIUM; CA2+;

D O I：

10.1007/978-1-4614-4756-6_16

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mitochondria Na+-Ca2+ exchange (NCXmit) was first discovered by Carafoli et al. in 1974. Thereafter, the mechanisms and roles of NCXmit have been extensively studied. We review NCXmit in cardiomyocytes and lymphocytes by presenting our recent studies on it. Studies of NCXmit in rat ventricular cells demonstrated that NCXmit is voltage dependent and electrogenic. A targeted knockdown and knockout of NCLX in HL-1 cardiomyocytes and B lymphocytes, respectively, significantly reduced the NCXmit activity, indicating that NCLX is a major component of NCXmit in these cells. The store-operated Ca2+ entry was greatly attenuated in NCLX knockout lymphocytes, suggesting that substantial amount of Ca2+ enters into mitochondria and is released to cytosol via NCXmit. NCXmit or NCLX has pivotal roles in Ca2+ handling in mitochondria and cytoplasm.

引用

页码：193 / 201

页数：9

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