Gender does not matter: Add-on repetitive transcranial magnetic stimulation treatment for female methamphetamine dependents

被引:34
作者
Liu, Ting [1 ,2 ,4 ]
Li, Yongqiang [3 ]
Shen, Ying [3 ]
Liu, Xiaoli [1 ,2 ]
Yuan, Ti-Fei [1 ,4 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China
[2] Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Rehabil Med Ctr, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
[4] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China
关键词
Transcranial magnetic stimulation; Female; Addiction; Craving; Methamphetamine; Gender; DORSOLATERAL PREFRONTAL CORTEX; SEX-DIFFERENCES; OVARIAN HORMONES; DRUG-ADDICTION; RTMS; EXCITABILITY; NETWORK; STRESS; PHASE;
D O I
10.1016/j.pnpbp.2018.12.018
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Repetitive transcranial magnetic stimulation (rTMS) targeting prefrontal cortex reduces craving in different types of drug addiction. However, most studies failed to elucidate the potential gender discrepancies for the treatment effects, due to the small percentage of female subjects enrolled. The present study prospectively recruited female methamphetamine dependents for TMS treatment. Methods: Ninety female methamphetamine dependents were randomly assigned into the control group (routine addiction rehabilitation) or add-on 10 Hz group (routine addiction rehabilitation plus 20 times rTMS treatments). The craving scores to drug associated cues were examined as the primary outcome for this treatment. Results: The results showed that add-on rTMS treatment was as well effective in female methamphetamine dependents, and the effect lasted for at least 30 days after treatment. Drug abuse history predicts the efficacy of chronic treatment, and the effects of TMS treatment was more pronounced in young, high-craving subjects. Conclusions: Add-on high frequency rTMS treatment is as well tolerable and effective in female methamphetamine dependents.
引用
收藏
页码:70 / 75
页数:6
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