EASL recommendations on treatment of hepatitis C: Final update of the series

被引:891
作者
Pawlotsky, Jean-Michel [1 ]
Negro, Francesco [1 ]
Aghemo, Alessio [1 ]
Berenguer, Marina [1 ]
Dalgard, Olav [1 ]
Dusheiko, Geoffrey [1 ]
Marra, Fiona [1 ]
Puoti, Massimo [1 ]
Wedemeyer, Heiner [1 ]
机构
[1] European Assoc Study Liver EASL, EASL Bldg Home Hepatol,7 Rue Daubin, CH-1203 Geneva, Switzerland
关键词
SUSTAINED VIROLOGICAL RESPONSE; DIRECT-ACTING ANTIVIRALS; VIRUS GENOTYPE 1; HCV-INFECTED PATIENTS; INJECTION-DRUG USE; HEPATOCELLULAR-CARCINOMA RECURRENCE; SOFOSBUVIR PLUS RIBAVIRIN; REAL-WORLD EFFECTIVENESS; CHRONIC VIRAL-HEPATITIS; RESISTANCE-ASSOCIATED SUBSTITUTIONS;
D O I
10.1016/j.jhep.2020.08.018
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, with approximately 71 million chronically infected individuals worldwide. Clinical care for patients with HCV-related liver disease has advanced considerably thanks to an enhanced understanding of the pathophysiology of the disease, as well as developments in diagnostic procedures and improvements in therapy and prevention. These therapies make it possible to eliminate hepatitis C as a major public health threat, as per the World Health Organization target, although the timeline and feasibility vary from region to region. These European Association for the Study of the Liver recommendations on treatment of hepatitis C describe the optimal management of patients with recently acquired and chronic HCV infections in 2020 and onwards. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1170 / 1218
页数:49
相关论文
共 385 条
[1]   Phase 3, Multicenter Open-Label study to investigate the efficacy of elbasvir and grazoprevir fixed-dose combination for 8 weeks in treatment-naive, HCV GT1b-infected patients, with non-severe fibrosis [J].
Abergel, Armand ;
Asselah, Tarik ;
Mallat, Arianne ;
Chanteranne, Brigitte ;
Faure, Frederic ;
Larrey, Dominique ;
Gournay, Jerome ;
Loustaud-Ratti, Veronique ;
Di Martino, Vincent ;
Fouchard-Hubert, Isabelle ;
Pol, Stanislas ;
Bailly, Francois ;
Samuel, Didier ;
Tran, Albert ;
Dodel, Marie ;
Andant, Nicolas ;
Lamblin, Geraldine ;
Muti, Leon ;
Reymond, Maud ;
Teilhet, Camille ;
Pereira, Bruno ;
Buchard, Benjamin .
LIVER INTERNATIONAL, 2020, 40 (08) :1853-1859
[2]   High efficacy of generic and brand direct acting antivirals in treatment of chronic hepatitis C [J].
Abozeid, Mai ;
Alsebaey, Ayman ;
Abdelsameea, Eman ;
Othman, Warda ;
Elhelbawy, Mostafa ;
Rgab, Amr ;
Elfayomy, Marwa ;
Abdel-Ghafar, Tamer Samir ;
Abdelkareem, Mervat ;
Sabry, Alyaa ;
Fekry, Marwa ;
Shebl, Nashwa ;
Rewisha, Eman ;
Waked, Imam .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 75 :109-114
[3]   Accuracy of Fibroscan, Compared With Histology, in Analysis of Liver Fibrosis in Patients With Hepatitis B or C: A United States Multicenter Study [J].
Afdhal, Nezam H. ;
Bacon, Bruce R. ;
Patel, Keyur ;
Lawitz, Eric J. ;
Gordon, Stuart C. ;
Nelson, David R. ;
Challies, Tracy L. ;
Nasser, Imad ;
Garg, Jyotsna ;
Wei, Lee-Jen ;
McHutchison, John G. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2015, 13 (04) :772-+
[4]   Epoetin alfa maintains ribavirin dose in HCV-infected patients: A prospective, double-blind, randomized controlled study [J].
Afdhal, NH ;
Dieterich, DT ;
Pockros, PJ ;
Schiff, ER ;
Shiffman, ML ;
Sulkowski, MS ;
Wright, T ;
Younossi, Z ;
Goon, BL ;
Tang, KL ;
Bowers, PJ .
GASTROENTEROLOGY, 2004, 126 (05) :1302-1311
[5]   Sofosbuvir/velpatasvir for 12 weeks in genotype 1-4 HCV-infected liver transplant recipients [J].
Agarwal, Kosh ;
Castells, Lluis ;
Mullhaupt, Beat ;
Rosenberg, William M. C. ;
McNabb, Brian ;
Arterburn, Sarah ;
Camus, Gregory ;
McNally, John ;
Stamm, Luisa M. ;
Brainard, Diana M. ;
Subramanian, G. Mani ;
Marino, Zoe ;
Dufour, Jean-Francois ;
Forns, Xavier .
JOURNAL OF HEPATOLOGY, 2018, 69 (03) :603-607
[6]  
Aghemo A, 2019, HEPATOLOGY, V70, p932A
[7]   Quantification of Core Antigen Monitors Efficacy of Direct-acting Antiviral Agents in Patients With Chronic Hepatitis C Virus Infection [J].
Aghemo, Alessio ;
Degasperi, Elisabetta ;
De Nicola, Stella ;
Bono, Patrizia ;
Orlandi, Anna ;
D'Ambrosio, Roberta ;
Soffredini, Roberta ;
Perbellini, Riccardo ;
Lunghi, Giovanna ;
Colombo, Massimo .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2016, 14 (09) :1331-1336
[8]   GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations [J].
Andrews, Jeff ;
Guyatt, Gordon ;
Oxman, Andrew D. ;
Alderson, Phil ;
Dahm, Philipp ;
Falck-Ytter, Yngve ;
Nasser, Mona ;
Meerpohl, Joerg ;
Post, Piet N. ;
Kunz, Regina ;
Brozek, Jan ;
Vist, Gunn ;
Rind, David ;
Akl, Elie A. ;
Schuenemann, Holger J. .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2013, 66 (07) :719-725
[9]  
[Anonymous], 2015, J HEPATOL, V63, P237, DOI 10.1016/j.jhep.2015.04.006
[10]  
[Anonymous], 2017, LANCET GASTROENTEROL