Natural products: a strategic lead generation approach in crop protection discovery

被引：89

作者：

Lorsbach, Beth A. ^{[1
]}

Sparks, Thomas C. ^{[1
]}

Cicchillo, Robert M. ^{[1
]}

Garizi, Negar V. ^{[1
]}

Hahn, Donald R. ^{[1
]}

Meyer, Kevin G. ^{[1
]}

机构：

[1] Dow AgroSci, Corteva AgrisciTM, Agr Div DowDuPontTM, Crop Protect Discovery, 9330 Zionsville Rd, Indianapolis, IN 46268 USA

来源：

PEST MANAGEMENT SCIENCE | 2019年 / 75卷 / 09期

关键词：

natural products; biologics; crop protection; lead generation; agrochemicals; genomics; ANTIFUNGAL ANTIBIOTICS; INSECTICIDE DISCOVERY; DRUG DISCOVERY; UK-2A; MEVALOCIDIN; PHYTOTOXIN; CHEMISTRY; FUNGICIDE; GENOMICS; ANALOGS;

D O I：

10.1002/ps.5350

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

With the anticipated population growth in the coming decades, the changing regulatory environment, and the continued emergence of resistance to commercial pesticides, there is a constant need to discover new lead chemistries with novel modes of action. We have established a portfolio of approaches to accelerate lead generation. One of these approaches capitalizes on the rich bioactivity of natural products (NPs), highlighted by the numerous examples of NP-based crop protection compounds. Within Corteva Agriscience and the affiliated preceding companies, NPs have been a fruitful approach, for nearly three decades, to identifying and bringing to the market crop protection products inspired by or originating from NPs, . Included in these NP-based crop protection products are the spinosyns family of insecticides, and those from more recent areas of NP-based fungicidal chemistry, as highlighted in this perspective. (c) 2019 Society of Chemical Industry

引用

页码：2301 / 2309

页数：9

共 62 条

[21] Discovery of the butenyl-spinosyn insecticides: Novel macrolides from the new bacterial strain Saccharopolyspora pogona [J].