Fish consumption and the risk of colorectal cancer: the Ohsaki Cohort Study

被引:17
作者
Sugawara, Y. [1 ]
Kuriyama, S.
Kakizaki, M.
Nagai, M.
Ohmori-Matsuda, K.
Sone, T.
Hozawa, A.
Nishino, Y. [2 ]
Tsuji, I.
机构
[1] Tohoku Univ, Grad Sch Med, Div Epidemiol, Dept Publ Hlth & Forens Med,Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Miyagi Prefectural Canc Res Ctr, Div Epidemiol, Natori, Miyagi, Japan
关键词
fish consumption; colorectal cancer; incidence; prospective cohort study; Japan; COLON-CANCER; MEAT CONSUMPTION; FATTY-ACIDS; WOMENS HEALTH; MEN; JAPAN; NUTRITION; FIBER; DIET;
D O I
10.1038/sj.bjc.6605217
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Evidence from laboratory and animal studies suggests that high fish consumption may reduce the risk of colorectal cancer, but the results of studies in humans have been inconsistent. The objective of this study was to prospectively examine the association between fish consumption and the risk of colorectal cancer incidence in Japan, where fish is widely consumed. METHODS: We analysed data from 39 498 men and women registered in the Ohsaki National Health Insurance Cohort Study who were 40-79 years old and free of cancer at the baseline. Fish consumption was assessed at the baseline using a self-administered food frequency questionnaire. RESULTS: During 9 years of follow-up, we identified 566 incident cases of colorectal cancer ( 379 men and 187 women). The hazard ratios and 95% confidence intervals (CIs) for colorectal cancer incidence in the highest quartile of fish consumption compared with the lowest quartile were 1.07 ( 95% CIs; 0.78-1.46, P-trend = 0.43) for men, and 0.96 ( 95% CIs; 0.61-1.53, P-trend = 0.69) for women. CONCLUSION: The results of this prospective cohort study revealed no association between fish consumption and the risk of colorectal cancer. British Journal of Cancer (2009) 101, 849-854. doi:10.1038/sj.bjc.6605217 www.bjcancer.com Published online 28 July 2009 (C) 2009 Cancer Research UK
引用
收藏
页码:849 / 854
页数:6
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