Bioinformatic analysis of miRNA-mRNA interaction associated with LMP2A gene in nasopharyngeal carcinoma

被引：0

作者：

Shi, Qianzhu ^{[1
]}

Ding, Yu ^{[2
]}

Yang, Yang ^{[1
]}

Liu, Shuzhen ^{[3
]}

Wang, Jiayi ^{[1
]}

Luo, Bing ^{[1
]}

机构：

[1] Qingdao Univ, Med Coll, Dept Pathogeny Biol, 38 Dengzhou Rd, Qingdao 266021, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Clin Lab, 59 Haier Rd, Qingdao 266003, Shandong, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Dept Blood Transfus, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China

来源：

FUTURE VIROLOGY | 2019年 / 14卷 / 06期

基金：

中国国家自然科学基金;

关键词：

hub genes; latent membrane protein 2A; nasopharyngeal carcinoma; EPSTEIN-BARR-VIRUS; EXPRESSION; CELLS; PROLIFERATION; TRANSCRIPTION; PROMOTES; INVASION;

D O I：

10.2217/fvl-2018-0167

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: The purpose of the study was to construct miRNA-mRNA network associated with LMP2A in nasopharyngeal carcinoma (NPC). Materials & methods: The dataset GSE53914, GSE12452 and GSE26596 were downloaded from Gene Expression Omnibus and differentially expressed genes (DEGs) identified by GEO2R. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed by ClusterProfiler R package. Protein-protein interaction network and mRNA-miRNA network associated with LMP2A were constructed. Hub genes were identified by Cytoscape. Results: The 135 DEGs associated with LMP2A were identified in NPC. Gene ontology function analysis showed DEGs were significantly enriched in cell-cell adhesion and NF-kappa B pathway. The hub genes were related to cell cycle. miRNA-mRNA network associated with LMP2A was constructed. Conclusion: The network may provide a way to explore the function of LMP2A in NPC by miRNA.

引用

页码：387 / 398

页数：12

共 37 条

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