Pd(OAc)2-catalyzed Domino reactions of 1-chloro-2-haloarenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes

被引：33

作者：

Dong, Cheng-Guo ^{[1
]}

Hu, Qiao-Sheng

机构：

[1] CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY 10314 USA

[2] CUNY Coll Staten Isl, Grad Ctr, Staten Isl, NY 10314 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 22期

关键词：

C-H ACTIVATION; HIGHLY EFFICIENT ROUTE; TANDEM REACTIONS; CATALYZED ANNULATION; METHOXY GROUPS; ARYL; VERSATILE; BENZYNES; COCYCLOTRIMERIZATION; CARBOSTANNYLATION;

D O I：

10.1021/ol061989i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-associated aryne generation strategy and Pd(OAc)(2)-catalyzed annulative Domino reactions of 1-chloro-2-halobenzenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes are described. The palladium-associated aryne generation strategy described here not only allows the high yield, one-step access to potentially useful substituted fluorenes from readily available 1-chloro-2-halobenzenes and 2-haloaryl tosylates, but may also lead to the development of other tandem reactions based on these readily available ortho leaving group bearing haloarenes.

引用

页码：5057 / 5060

页数：4

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