Effects of L-arginine on various types of pain sensitivity

被引：4
|
作者：
Severyanova, L. A. [1 ]
Bobyntsev, I. I. [1 ]
Kir'yanova, N. A. [1 ]
Dolgintsev, A. E. [1 ]
机构：
[1] Kursk State Med Univ, Dept Pathophysiol, Kursk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 05期
关键词：
L-arginine; pain; electrocutaneous stimulation; thermal pain stimulation;
D O I：
10.1007/s10517-006-0222-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Intraperitoneal injection of L-arginine to male Wistar rats 12 min before the start of the experiment produced a nociceptive effect on models of electrocutancous stimulation of the tail or hot-plate test and increased nociceptive behavior due to high sensitivity of supraspinal nociceptive structures to this compound. The nociceptive effect of this amino acid was more pronounced and persistent under conditions of electrocutaneous stimulation.
引用
收藏
页码：567 / 570
页数：4
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