oxLDL/β2GPI complex and anti-oxLDL/β2GPI in SLE: Prevalence and correlates

被引:15
|
作者
Bassi, N. [1 ]
Zampieri, S. [1 ]
Ghirardello, A. [1 ]
Tonon, M. [1 ]
Zen, M. [1 ]
Beggio, S. [1 ]
Matsuura, E. [2 ]
Doria, A. [1 ]
机构
[1] Univ Padua, Div Rheumatol, Dept Med & Surg Sci, I-35128 Padua, Italy
[2] Okayama Univ, Sch Med, Dept Cell Chem, Inst Cellular & Mol Biol, Okayama 7008558, Japan
关键词
SLE; atherosclerosis; oxLDL; beta; 2GPI; oxLDL/beta 2GPI complex; AAb; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ATHEROSCLEROSIS; AUTOANTIBODIES; MANIFESTATIONS; STRESS;
D O I
10.1080/08916930902828247
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
High levels of oxidized low-density liprotein/beta2 glycoprotein 1 (oxLDL/beta 2GPI) complexes and anti-complex IgG as well as IgM have been reported in SLE. We analysed this complex and Ab against the complex in SLE patients and evaluated their relationship with clinical and serological findings, traditional risk factors for atherosclerosis, and subclinical atherosclerosis. The prevalence and the levels of the complex and of anti-complex Ab were significantly higher in systemic lupus erythematosus (SLE) patients than in normal healthy donors (NHD). The titers of oxLDL/beta 2GPI were significantly higher in patients with renal involvement and previous thromboembolic episodes and were correlated with the number of risk factors for atherosclerosis, whereas they were significantly lower in patients with neurological involvement. Both IgG and IgM anticomplex Ab were associated with antiphospholipid (APL). In conclusion, the oxLDL/beta 2GPI complex as well as Ab against the complex are prevalent in SLE where they seem to be involved in organ damage.
引用
收藏
页码:289 / 291
页数:3
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