CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression

被引：76
|
作者：
Kong, Yanan [1 ,2 ,3 ]
Yang, Lu [1 ,2 ,3 ]
Wei, Weidong [1 ,2 ,3 ]
Lyu, Ning [2 ,3 ,4 ]
Zou, Yutian [1 ,2 ,3 ]
Gao, Guanfeng [1 ,2 ,3 ]
Ou, Xueqi [1 ,2 ,3 ]
Xie, Xiaoming [1 ,2 ,3 ]
Tang, Hailin [1 ,2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[2] State Key Lab Oncol South China, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[3] Collaborat Innovat Ctr Canc Med, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Dept Minimally Invas Intervent Radiol, Canc Ctr, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
来源：
EPIGENOMICS | 2019年 / 11卷 / 10期
基金：
中国国家自然科学基金;
关键词：
ceRNAs; circPLK1; circRNAs; MiR-296-5p; miRNAs; PLK1; prognosis; therapy; triple-negative breast cancer; tumor occurrence and metastasis; POLO-LIKE KINASE; POTENTIAL THERAPEUTIC TARGET; SMALL-MOLECULE INHIBITOR; CIRCULAR RNAS; PROGNOSTIC-SIGNIFICANCE; PLK EXPRESSION; GROWTH; IDENTIFICATION; MARKER;
D O I：
10.2217/epi-2019-0093
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. Materials & methods: We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments in vitro and in vivo were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and PLK1 in TNBC. Results & conclusion: CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.
引用
收藏
页码：1163 / 1176
页数：14
相关论文
共 50 条
  • [21] miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells
    Wang, Huiling
    Fang, Qian
    You, Shuo
    Wu, Yaqin
    Zhang, Chaojie
    GENES & GENOMICS, 2023, 45 (01) : 39 - 47
  • [22] Inhibitory effect of miR342 on the progression of triple-negative breast cancer cells in vitro and in the mice model
    Alidoost, Zahra
    Attari, Farnoosh
    Saadatpour, Fatemeh
    Arefian, Ehsan
    BIOIMPACTS, 2024, 14 (01)
  • [23] miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells
    Li, Dengfeng
    Hu, Jiashu
    Song, Hongming
    Xu, Hui
    Wu, Chengyang
    Zhao, Bingkun
    Xie, Dan
    Wu, Tianqi
    Zhao, Junyong
    Fang, Lin
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 9 (05): : 2276 - 2285
  • [24] CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1
    Lin, Yuxiang
    Zhang, Jie
    Li, Yan
    Guo, Wenhui
    Chen, Lili
    Chen, Minyan
    Chen, Xiaobin
    Zhang, Wenzhe
    Jin, Xuan
    Jiang, Meichen
    Xiao, Han
    Wang, Chuan
    Song, Chuangui
    Fu, Fangmeng
    JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)
  • [25] lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p
    Yi Peng
    Xiaoxi Huang
    Hongmei Wang
    BMC Molecular and Cell Biology, 23
  • [26] miR-155-5p antagonizes the apoptotic effect of bufalin in triple-negative breast cancer cells
    Wang, Qian
    Li, Ce
    Zhu, Zhitu
    Teng, Yuee
    Che, Xiaofang
    Wang, Yan
    Ma, Yanju
    Wang, Yiding
    Zheng, Huachuan
    Liu, Yunpeng
    Qu, Xiujuan
    ANTI-CANCER DRUGS, 2016, 27 (01) : 9 - 16
  • [27] LncRNA-MALAT1 promotes triple-negative breast cancer progression and function as ceRNA to target REEP5 by sponging miR-106a-5p
    Yang, Qiu-hui
    Fu, Ye-qin
    Feng, Wei-liang
    Mao, Jie-fei
    Xu, Ning
    Liu, Qing
    Yan, Qian-jun
    Yang, Hong-jian
    Zhang, Xi-ping
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2025, 30 (01) : 159
  • [28] lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p
    Peng, Yi
    Huang, Xiaoxi
    Wang, Hongmei
    BMC MOLECULAR AND CELL BIOLOGY, 2022, 23 (01)
  • [29] CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A
    Feng, Dandan
    Gao, Jie
    Liu, Ruiqiong
    Liu, Wei
    Gao, Tianyang
    Yang, Yunkai
    Zhang, Die
    Yang, Tianshu
    Yin, Xin
    Yu, Hefen
    Huang, Wei
    Wang, Yan
    PROTEIN & CELL, 2024, 15 (10) : 744 - 765
  • [30] MiR-34b is associated with clinical outcome in triple-negative breast cancer patients
    Svoboda, Marek
    Sana, Jiri
    Redova, Martina
    Navratil, Jiri
    Palacova, Marketa
    Fabian, Pavel
    Slaby, Ondrej
    Vyzula, Rostislav
    DIAGNOSTIC PATHOLOGY, 2012, 7
12345