CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression

被引：76
|
作者：
Kong, Yanan [1 ,2 ,3 ]
Yang, Lu [1 ,2 ,3 ]
Wei, Weidong [1 ,2 ,3 ]
Lyu, Ning [2 ,3 ,4 ]
Zou, Yutian [1 ,2 ,3 ]
Gao, Guanfeng [1 ,2 ,3 ]
Ou, Xueqi [1 ,2 ,3 ]
Xie, Xiaoming [1 ,2 ,3 ]
Tang, Hailin [1 ,2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[2] State Key Lab Oncol South China, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[3] Collaborat Innovat Ctr Canc Med, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Dept Minimally Invas Intervent Radiol, Canc Ctr, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
来源：
EPIGENOMICS | 2019年 / 11卷 / 10期
基金：
中国国家自然科学基金;
关键词：
ceRNAs; circPLK1; circRNAs; MiR-296-5p; miRNAs; PLK1; prognosis; therapy; triple-negative breast cancer; tumor occurrence and metastasis; POLO-LIKE KINASE; POTENTIAL THERAPEUTIC TARGET; SMALL-MOLECULE INHIBITOR; CIRCULAR RNAS; PROGNOSTIC-SIGNIFICANCE; PLK EXPRESSION; GROWTH; IDENTIFICATION; MARKER;
D O I：
10.2217/epi-2019-0093
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. Materials & methods: We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments in vitro and in vivo were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and PLK1 in TNBC. Results & conclusion: CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.
引用
收藏
页码：1163 / 1176
页数：14
相关论文
共 50 条
  • [1] Circular RNAs as miRNA sponges in triple-negative breast cancer: a systematic review
    Kohansal, Maryam
    Tang, Hailin
    Xie, Xiaoming
    Taghinezhad, Ali
    Ghanbariasad, Ali
    MINERVA BIOTECNOLOGICA, 2020, 32 (02) : 79 - 87
  • [2] lncRNA SEMA3B-AS1 Inhibits miR-513c-5p to Regulate the Progression of Triple-negative Breast Cancer
    Yu, Haizhen
    Wu, Yang
    Huang, Jianyuan
    Li, Shizhen
    ANTICANCER RESEARCH, 2023, 43 (12) : 5475 - 5483
  • [3] circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis
    Liu, Peng
    Zou, Yutian
    Li, Xing
    Yang, Anli
    Ye, Feng
    Zhang, Jie
    Wei, Weidong
    Kong, Yanan
    FRONTIERS IN GENETICS, 2020, 11
  • [4] circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression
    Chen, Bo
    Wei, Weidong
    Huang, Xiaojia
    Xie, Xinhua
    Kong, Yanan
    Dai, Danian
    Yang, Lu
    Wang, Jin
    Tang, Hailin
    Xie, Xiaoming
    THERANOSTICS, 2018, 8 (14): : 4003 - 4015
  • [5] MiR-150-5p Overexpression in Triple-Negative Breast Cancer Contributes to the In Vitro Aggressiveness of This Breast Cancer Subtype
    Sugita, Bruna M.
    Rodriguez, Yara
    Fonseca, Aline S.
    Souza, Emanuelle Nunes
    Kallakury, Bhaskar
    Cavalli, Iglenir J.
    Ribeiro, Enilze M. S. F.
    Aneja, Ritu
    Cavalli, Luciane R.
    CANCERS, 2022, 14 (09)
  • [6] ETS1 is a prognostic biomarker of triple-negative breast cancer and promotes the triple-negative breast cancer progression through the YAP signaling
    Li, Yanlin
    Wu, Tiantian
    Peng, Ziluo
    Tian, Xianyan
    Dai, Qian
    Chen, Miao
    Zhu, Jun
    Xia, Song
    Sun, Aiqin
    Yang, Wannian
    Lin, Qiong
    AMERICAN JOURNAL OF CANCER RESEARCH, 2022, 12 (11): : 5074 - 5084
  • [7] The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
    Li, Yao
    Meng, Xue
    Luo, Yuqing
    Luo, Shuai
    Li, Jin
    Zeng, Jiafei
    Huang, Xiang
    Wang, Jinjing
    AGING-US, 2023, 15 (18): : 9809 - 9821
  • [8] Research on correlations of miR-585 expression with progression and prognosis of triple-negative breast cancer
    Yao, Minya
    Wang, Shuqian
    Chen, Luyan
    Wei, Bajin
    Fu, Peifen
    CLINICAL AND EXPERIMENTAL MEDICINE, 2022, 22 (02) : 201 - 207
  • [9] Research on correlations of miR-585 expression with progression and prognosis of triple-negative breast cancer
    Minya Yao
    Shuqian Wang
    Luyan Chen
    Bajin Wei
    Peifen Fu
    Clinical and Experimental Medicine, 2022, 22 : 201 - 207
  • [10] miR-374a-5p promotes tumor progression by targeting ARRB1 in triple negative breast cancer
    Son, Dasom
    Kim, Yesol
    Lim, Sera
    Kang, Hyeok-Gu
    Kim, Da-Hyun
    Park, Jee Won
    Cheong, Woosung
    Kong, Hyun Kyung
    Han, Wonshik
    Park, Woong-Yang
    Chun, Kyung-Hee
    Park, Jong Hoon
    CANCER LETTERS, 2019, 454 : 224 - 233
12345