Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

被引：111
作者：
Lee, DG
Park, Y
Kim, MR
Jung, HJ
Seu, YB
Hahm, KS
Woo, ER [1 ]
机构：
[1] Chosun Univ, Res Ctr Prot Mat, Kwangju 501759, South Korea
[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea
[3] Kyungpook Natl Univ, Dept Microbiol, Taegu 702701, South Korea
来源：
BIOTECHNOLOGY LETTERS | 2004年 / 26卷 / 14期
关键词：
anti-fungal activity; trans-N-caffeoyltyramine; dihydro-N-caffeoyltyramine; trans-N-feruloyloctopamine; Lycium chinense; Solanaceae;
D O I：
10.1023/B:BILE.0000035483.85790.f7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Four phenolic amides, dihydro-N-caffeoyltyramine ( 1), trans-N-feruloyloctopamine ( 2), trans-N-caffeoyltyramine ( 3), and cis-N-caffeoyltyramine ( 4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 mug ml(-1) and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 mug ml(-1). All four compounds impeded the dimorphic transition of pathogen, Candida albicans.
引用
收藏
页码：1125 / 1130
页数：6
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