Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

被引：110

作者：

Lee, DG

Park, Y

Kim, MR

Jung, HJ

Seu, YB

Hahm, KS

Woo, ER ^{[1
]}

机构：

[1] Chosun Univ, Res Ctr Prot Mat, Kwangju 501759, South Korea

[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

[3] Kyungpook Natl Univ, Dept Microbiol, Taegu 702701, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2004年 / 26卷 / 14期

关键词：

anti-fungal activity; trans-N-caffeoyltyramine; dihydro-N-caffeoyltyramine; trans-N-feruloyloctopamine; Lycium chinense; Solanaceae;

D O I：

10.1023/B:BILE.0000035483.85790.f7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four phenolic amides, dihydro-N-caffeoyltyramine ( 1), trans-N-feruloyloctopamine ( 2), trans-N-caffeoyltyramine ( 3), and cis-N-caffeoyltyramine ( 4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 mug ml(-1) and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 mug ml(-1). All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

引用

页码：1125 / 1130

页数：6

共 38 条

[1] Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense
Dong Gun Lee
Yoonkyung Park
Mi-Ran Kim
Hyun Jun Jung
Young Bae Seu
Kyung-Soo Hahm
Eun-Rhan Woo
Biotechnology Letters, 2004, 26 : 1125 - 1130
[2] Sesquiterpenoids isolated from the root bark of Lycium chinense
Wang, Xiao-xia
Liu, Qian
Wang, Ning
Zhang, Rui-li
Li, Xiao
Zhuang, Peng-yu
Liu, Hang
Sun, Liang-dan
Jin, Yang
PHYTOCHEMISTRY, 2025, 235
[3] Antihyperlipidemic glycosides from the root bark of Lycium chinense
Chen, Hui
Li, Yu-Jie
Sun, Yan-Jun
Li, Xiao-Kun
Jian-Hong, Gong
Wu, Ya
Su, Fang-Yi
Du, Kun
Zhang, Yan-Li
Feng, Wei-Sheng
NATURAL PRODUCT RESEARCH, 2019, 33 (18) : 2655 - 2661
[4] Nine compounds from the Root Bark of Lycium chinense and their anti-inflammatory activities
Yang, Yanan
An, Yawen
Wang, Wei
Du, Ning
Zhang, Jinghua
Feng, Ziming
Jiang, Jianshuang
Zhang, Peicheng
ACTA PHARMACEUTICA SINICA B, 2017, 7 (04) : 491 - 495
[5] Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities
Yanan Yang
Yawen An
Wei Wang
Ning Du
Jinghua Zhang
Ziming Feng
Jianshuang Jiang
Peicheng Zhang
Acta Pharmaceutica Sinica B, 2017, 7 (04) : 491 - 495
[6] A new phenolic amide from Lycium chinense Miller
Han, SH
Lee, HH
Lee, IS
Moon, YH
Woo, ER
ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (04) : 433 - 437
[7] New long-chain hydroxyalkyl ferulates from the root bark of Lycium chinense Mill.
Pan, Shu
Hou, Ai-Jun
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, 11 (07) : 681 - 685
[8] Three new lignanamides from the root of Lycium chinense with anti-inflammatory activity
Chen, Fang
Huang, Xiao-jun
Liang, Qiu-ping
Huang, Yuan-peng
Lan, Ting
Zhou, Guang-xiong
NATURAL PRODUCT RESEARCH, 2019, 33 (23) : 3378 - 3382
[9] Antimicrobial property of (+)-lyoniresinol-3α-O-β-D-glucopyranoside isolated from the root bark of Lycium chinense Miller against human pathogenic microorganisms
Lee, DG
Jung, HJ
Woo, ER
ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (09) : 1031 - 1036
[10] Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice
Chen, Hongxia
Olatunji, Opeyemi J.
Zhou, Yifeng
JOURNAL OF NATURAL MEDICINES, 2016, 70 (03) : 610 - 619

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