Long-term studies of treatments for type 2 diabetes

被引:8
作者
Caballero, A. Enrique [1 ]
机构
[1] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA USA
关键词
alpha-Glucosidase inhibitors; glucose-lowering therapies; incretin-based therapies; insulin; type; 2; diabetes; BETA-CELL FUNCTION; OBSERVATIONAL FOLLOW-UP; PIOGLITAZONE CLINICAL-TRIAL; METFORMIN-TREATED PATIENTS; GLYCEMIC CONTROL; CARDIOVASCULAR OUTCOMES; INSULIN GLARGINE; OPEN-LABEL; MACROVASCULAR DISEASE; JAPANESE PATIENTS;
D O I
10.1080/00325481.2017.1265417
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is a relative lack of long-term data for individual glucose-lowering therapies for the treatment of type 2 diabetes mellitus. A systematic search of published literature reporting data of approximately 3years of follow-up from randomized controlled trials and their extensions was conducted. Trials to evaluate the efficacy and/or safety of glucose-lowering drugs currently approved for the treatment of adults with type 2 diabetes were included. Search results included long-term published data for traditional oral glucose-lowering drugs, insulin, -glucosidase inhibitors, and incretin-based therapies. In general, results indicated that the short-term risk/benefit profile of these therapies is in line with longer-term evaluations. Individual results from these trials are reviewed in this report. These findings support the use of approved drug classes for longer-term treatment of type 2 diabetes.
引用
收藏
页码:352 / 365
页数:14
相关论文
共 69 条
  • [1] Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes:: a 4-year follow-up
    Alvarsson, M.
    Sundkvist, G.
    Lager, I.
    Berntorp, K.
    Fernqvist-Forbes, E.
    Steen, L.
    Orn, T.
    Holberg, M. A.
    Kirksaether, N.
    Grill, V.
    [J]. DIABETES OBESITY & METABOLISM, 2008, 10 (05) : 421 - 429
  • [2] Alvarsson Michael, 2010, Rev Diabet Stud, V7, P225, DOI 10.1900/RDS.2010.7.225
  • [3] Standards of Medical Care in Diabetes-2014
    不详
    [J]. DIABETES CARE, 2014, 37 : S14 - S80
  • [4] Introduction
    不详
    [J]. DIABETES CARE, 2015, 38 : S1 - S2
  • [5] Rosiglitazone and Outcomes for Patients With Diabetes Mellitus and Coronary Artery Disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
    Bach, Richard G.
    Brooks, Maria Mori
    Lombardero, Manuel
    Genuth, Saul
    Donner, Thomas W.
    Garber, Alan
    Kennedy, Laurence
    Monrad, E. Scott
    Pop-Busui, Rodica
    Kelsey, Sheryl F.
    Frye, Robert L.
    [J]. CIRCULATION, 2013, 128 (08) : 785 - 794
  • [6] NIDDM: A rapid progressive disease - Results from a long-term, randomised, comparative study of insulin or sulphonylurea treatment
    Birkeland, KI
    Rishaug, U
    Hanssen, KF
    Vaaler, S
    [J]. DIABETOLOGIA, 1996, 39 (12) : 1629 - 1633
  • [7] Effects of Exenatide on Measures of β-Cell Function After 3 Years in Metformin-Treated Patients With Type 2 Diabetes
    Bunck, Mathijs C.
    Corner, Anja
    Ellasson, Bjorn
    Heine, Robert J.
    Shaginian, Rimma M.
    Taskinen, Marja-Riitta
    Smith, Ulf
    Yki-Jarvinen, Hannele
    Diamant, Michaela
    [J]. DIABETES CARE, 2011, 34 (09) : 2041 - 2047
  • [8] One-year Treatment With Exenatide Improves β-Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients A randomized, controlled trial
    Bunck, Mathijs C.
    Diamant, Michaela
    Corner, Anja
    Eliasson, Bjorn
    Malloy, Jaret L.
    Shaginian, Rimma M.
    Deng, Wei
    Kendall, David M.
    Taskinen, Marja-Riitta
    Smith, Ulf
    Yki-Jarvinen, Hannele
    Heine, Robert J.
    [J]. DIABETES CARE, 2009, 32 (05) : 762 - 768
  • [9] Action to control cardiovascular risk in diabetes (ACCORD) trial: Design and methods
    Buse, John B.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (12A) : 21I - 33I
  • [10] Pioglitazone Use in Combination with Insulin in the Prospective Pioglitazone Clinical Trial in Macrovascular Events Study (PROactive19)
    Charbonnel, Bernard
    DeFronzo, Ralph
    Davidson, Jaime
    Schmitz, Ole
    Birkeland, Kare
    Pirags, Valdis
    Scheen, Andre
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (05) : 2163 - 2171