Emerging methods for the fabrication of polymer capsules

被引:164
作者
Cui, Jiwei [1 ]
van Koeverden, Martin P. [1 ]
Muellner, Markus [1 ]
Kempe, Kristian [1 ]
Caruso, Frank [1 ]
机构
[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia
基金
澳大利亚研究理事会;
关键词
Nanoparticles; Polymer architecture; Assembly; Layer-by-layer; Drug delivery; Nanotechnology; LIVING RADICAL POLYMERIZATION; POLYELECTROLYTE MULTILAYER CAPSULES; BLOCK-COPOLYMER VESICLES; SELF-ASSEMBLY PROCESS; CATIONIC BIPOLAR AMPHIPHILES; ENZYME-LOADED LIPOSOMES; DRUG-DELIVERY; HOLLOW NANOSPHERES; CONTROLLED-RELEASE; CANCER-CELLS;
D O I
10.1016/j.cis.2013.10.012
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Hollow polymer capsules are attracting increasing research interest due to their potential application as drug delivery vectors, sensors, biomimetic nano- or multi-compartment reactors and catalysts. Thus, significant effort has been directed toward tuning their size, composition, morphology, and functionality to further their application. In this review, we provide an overview of emerging techniques for the fabrication of polymer capsules, encompassing: self-assembly, layer-by-layer assembly, single-step polymer adsorption, bio-inspired assembly, surface polymerization, and ultrasound assembly. These techniques can be applied to prepare polymer capsules with diverse functionality and physicochemical properties, which may fulfill specific requirements in various areas. In addition, we critically evaluate the challenges associated with the application of polymer capsules in drug delivery systems. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:14 / 31
页数:18
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