Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities

被引：7

作者：

Kumar, Sandeep ^{[1
]}

Kumar, Nikhil ^{[2
]}

Roy, Partha ^{[2
]}

Sondhi, Sham M. ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Indian Inst Technol Roorkee, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 09期

关键词：

Synthesis; 2,6-Dioxopiperazine derivatives; Anti-inflammatory; Anticancer; AMIDINE DERIVATIVES; COLON-CANCER; COX-2; DIKETOPIPERAZINES; INHIBITORS; DESIGN; ASSAY;

D O I：

10.1007/s00044-014-0969-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Piperazine dione derivatives (1a-j) on condensation with 2,6-pyridine dicarboxylic acid (2x), 3,5-pyridine dicarboxylic acid (2y) and 2,5-thiophene dicarboxylic acid (2z) gave corresponding heterocyclic compounds 3ax-3jz in excellent yields. All the newly synthesized compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory and for in vitro anticancer activity, compounds 3bx, 3cx, 3dx, and 3ex exhibited good anti-inflammatory activity, whereas compounds 3ay, 3az, 3cz, 3dx, 3ez, 3fx, 3gx, and 3hz exhibited good anticancer activity.

引用

页码：3953 / 3969

页数：17

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