Fusion and Self-Assembly of Biodegradable Polymer Particles into Scaffold like and Membrane like Structures at Room Temperature for Regenerative Medicine

被引:6
作者
Rajmohan, G. [1 ]
Admane, Prasad [1 ]
Anish, Chakkumkal [1 ]
Panda, Amulya K. [1 ]
机构
[1] Natl Inst Immunol, New Delhi 110067, India
关键词
polylactide particles; surfactant mediated fusion; scaffold; cell growth; controlled release; wound healing; POLY(L-LACTIC ACID); TUMOR-MODEL; TISSUE; MICROSPHERES; NANOPARTICLES; BIOMATERIALS; FABRICATION; INFECTIONS; WOUNDS;
D O I
10.1021/mp500106u
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We report here a novel surfactant mediated fusion of polylactide particles into scaffoldlike structures at room temperature. In the presence of ethanol, evenly spread surfactant coated polylactide particles fused immediately into membranelike structures. Polymer scaffolds of the desired shape and size could be fabricated from polylactide particles using this fusion process. Desorption of surfactant molecules from the surface of the particles during ethanol treatment and the degree of solubility of the polymer in alcohol were found to be the main reasons for the fusion of particles into a scaffold at room temperature. TGA and DSC studies of the polylactide particles showed that the particles were stable at room temperature, and FTIR studies showed that there was no change in characteristics of the polymer after the fusion of particles into a scaffold-type structure. These scaffolds supported three-dimensional growth of animal cells in vitro and release model protein in a sustained manner for a long period of time. In an experimental animal wound model, the polylactide membranes showed faster wound closure, indicating its use as a passive dressing material. This polymer particle fusion process thus provides a novel method of scaffold fabrication for various biomedical applications.
引用
收藏
页码:2190 / 2202
页数:13
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