Cell-free DNA as a prognostic marker in stage I non-small-cell lung cancer patients undergoing stereotactic body radiotherapy

被引：14

作者：

Bortolin, Maria Teresa ^{[1
]}

Tedeschi, Rosamaria ^{[1
]}

Bidoli, Ettore ^{[2
]}

Furlan, Carlo ^{[3
]}

Basaglia, Giancarlo ^{[1
]}

Minatel, Emilio ^{[3
]}

Gobitti, Carlo ^{[3
]}

Franchin, Giovanni ^{[3
]}

Trovo, Marco ^{[3
]}

De Paoli, Paolo ^{[4
]}

机构：

[1] IRCCS, Oncol Reference Ctr, Microbiol Immunol & Virol Unit, I-33081 Aviano, PN, Italy

[2] IRCCS, Oncol Reference Ctr, Epidemiol & Biostat Unit, I-33081 Aviano, PN, Italy

[3] IRCCS, Oncol Reference Ctr, Med Radiotherapy Dept, I-33081 Aviano, PN, Italy

[4] IRCCS, Oncol Reference Ctr, Sci Directorate, I-33081 Aviano, PN, Italy

来源：

BIOMARKERS | 2015年 / 20卷 / 6-7期

关键词：

Biomarker; cell-free DNA; early stage; lung cancer; stereotactic body radiotherapy; CIRCULATING PLASMA DNA; ABLATIVE RADIOTHERAPY; RADIATION-THERAPY; CLINICAL-PRACTICE; QUANTIFICATION; RECURRENCE; DIAGNOSIS; BIOMARKER; PATTERNS; TUMORS;

D O I：

10.3109/1354750X.2015.1094139

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To evaluate whether plasma cell-free DNA (cfDNA) was related to clinical outcome in inoperable stage I non-small cell lung cancer (NSCLC) patients undergoing stereotactic body radiotherapy (SBRT).Materials and methods: Plasma cfDNA was assessed at baseline, before the last day and 45 days after the end of SBRT, in 22 NSCLC patients. Twenty-two healthy controls were also evaluated.Results: Plasma cfDNA was higher in patients than in controls. An association with unfavourable disease-free survival was found for continuous baseline cfDNA increments (HR=5.9, 95%CI: 1.7-19.8, p=0.04).Conclusion: Plasma cfDNA may be a promising prognostic biomarker in high-risk NSCLC patients.

引用

页码：422 / 428

页数：7

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